63571-77-7

Upstream product

• 136918-14-4 phthalimide 
• 506-68-3 bromocyane 
• 1074-82-4 potassium phtalimide 

Downstream Products

• 1192739-68-6 2-(2-cyclohexyl-5,6,7,8-tetrahydroquinazolin-4-yl)isoindoline-1,3-dione 
• 1192739-69-7 2-(6-methoxy-2-phenylquinazolin-4-yl)isoindoline-1,3-dione 
• 74764-51-5 2-(pyridine-2-yl)benzonitrile 
• 520-03-6 N-phenylphthalimide 

Relevant academic research and scientific papers

N-Cyanoimides via the cyanation of imides

The conversion of cyclic imides to the corresponding N-cyanoimides has been carried out using cyanogen bromide as the nitrile source. This methodology provides a convenient route for the preparation of both aromatic and aliphatic N-cyanoimides.

A convenient synthesis of benzonitriles via electrophilic cyanation with N-cyanobenzimidazole

(Chemical Equation Presented) Couplings: N-Cyanobenzimidazole has been used in the synthesis of aryl- and heteroarylnitriles from the corresponding Grignard reagents (see scheme). This electrophilic cyanation is further extended to the synthesis of 2-cyano1,1'-biaryls through a domino Grignard-coupling/ cyanation strategy.

Quantitative gas-solid reactions with ClCN and BrCN: Synthesis of cyanamides, cyanates, thiocyanates, and their derivatives

Gas-solid reaction techniques allow quantitative cyanations with ClCN and BrCN. Three primary and four secondary cyanamides, a cyanimide, four cyanates, and four thiocyanates were all prepared as solids in 100% yield from solid anilines, benzimidazoles, imides, phenolates, and thiolates, respectively. Intramolecular solid-state reactions of cyanated o-aminophenol and of cyanated hydrazides gave heterocyclic compounds. When comparable reactions were performed in solution the reported product yields were considerably less than 100% in all cases. The reasons for the success of the environmentally benign solid-state syntheses are discussed in terms of phase rebuilding, phase transformation, and crystal disintegration. Atomic force microscopy (AFM) of selected systems indicates the occurrence of long-range molecular movements which are governed by the crystal packing. This is evident from the obvious correlations between the molecular movements and the known crystal packing data. A new type of geometric surface feature, a rectangular and a rhombic depression which resembles a swimming-pool basin, was found in the cyanation of o-aminophenol and benzohydrazide.