63572-67-8 Usage
Explanation
Different sources of media describe the Explanation of 63572-67-8 differently. You can refer to the following data:
1. The compound's chemical composition consists of 11 carbon atoms, 7 hydrogen atoms, 1 chlorine atom, 4 nitrogen atoms, and 1 oxygen atom.
2. The physical form of the compound is a yellow to brown colored powder.
3. The compound dissolves easily in organic solvents such as ethanol and dimethyl sulfoxide, which is useful for its handling and application in research and pharmaceuticals.
4. Potential use as an antifungal agent
4. Studies have been conducted on the compound to explore its potential as an antifungal agent, which could be useful in treating fungal infections.
5. Inhibitory effects on certain enzymes
5. The compound has been shown to have inhibitory effects on specific enzymes, which could be beneficial in the development of new therapies for various medical conditions.
6. The compound's structure contains a benzimidazole ring, a chlorine atom, and a nitrile group attached to a ketone. These features make it a versatile molecule for medicinal chemistry and drug development.
7. Applications in research and pharmaceuticals
7. Due to its unique structure and properties, the compound is commonly used in research and pharmaceutical applications to better understand biological systems and develop new therapies for various medical conditions.
Appearance
Yellow to brown powder
Solubility
Soluble in organic solvents like ethanol and dimethyl sulfoxide
Structural features
Benzimidazole ring, chlorine atom, nitrile group, and ketone
Check Digit Verification of cas no
The CAS Registry Mumber 63572-67-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,5,7 and 2 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 63572-67:
(7*6)+(6*3)+(5*5)+(4*7)+(3*2)+(2*6)+(1*7)=138
138 % 10 = 8
So 63572-67-8 is a valid CAS Registry Number.
63572-67-8Relevant articles and documents
Design, synthesis and biological evaluation of 5-amino-4-(1H-benzoimidazol-2-yl)-phenyl-1,2-dihydro-pyrrol-3-ones as inhibitors of protein kinase FGFR1
Gryshchenko,Tarnavskiy,Levchenko,Bdzhola,Volynets,Golub,Ruban,Vygranenko,Lukash,Yarmoluk
, p. 2053 - 2059 (2016/04/20)
Fibroblast growth factor receptor 1 (FGFR1) plays an important role in tumorigenesis and is therefore an attractive target for anticancer therapy. Using molecular docking approach we have identified inhibitor of FGFR1 belonging to 5-amino-4-(1H-benzoimidazol-2-yl)-phenyl-1,2-dihydro-pyrrol-3-ones with IC50 value of 3.5 μM. A series of derivatives of this chemical scaffold has been synthesized and evaluated for inhibition of FGFR1 kinase activity. It was revealed that the most promising compounds 5-amino-1-(3-hydroxy-phenyl)-4-(6-methyl-1H-benzoimidazol-2-yl)-1,2-dihydro-pyrrol-3-one and 5-amino-4-(1H-benzoimidazol-2-yl)-1-(3-hydroxy-phenyl)-1,2-dihydro-pyrrol-3-one inhibit FGFR1 with IC50 values of 0.63 and 0.32 μM, respectively, and posses antiproliferative activity against KG1 myeloma cell line with IC50 values of 5.6 and 9.3 μM. Structure-activity relationships have been studied and binding mode of this chemical class has been proposed.
