635752-00-0Relevant academic research and scientific papers
Catalyst-Free Annulation of 2-Pyridylacetates and Ynals with Molecular Oxygen: An Access to 3-Acylated Indolizines
Chen, Zhengwang,Liang, Pei,Ma, Xiaoyue,Luo, Haiqing,Xu, Guohai,Liu, Tanggao,Wen, Xiaowei,Zheng, Jing,Ye, Hui
supporting information, p. 1630 - 1639 (2019/01/26)
A catalyst and additive-free annulation of 2-pyridylacetates and ynals under molecular oxygen was the first developed, affording 3-acylated indolizines in good to excellent yields. Molecular oxygen was used as the source of the carbonyl oxygen atom in indolizines. This approach was compatible with a wide range of functional groups, and especially it has been successfully extended to unsaturated double bonds and triple bonds, which were difficult to prepare by previous methods in a single step.
Metal-free aminothiation of alkynes: Three-component tandem annulation toward indolizine thiones from 2-alkylpyridines, ynals, and elemental sulfur
Chen, Zhengwang,Liang, Pei,Xu, Fan,Deng, Zhen,Long, Lipeng,Luo, Guotian,Ye, Min
supporting information, p. 12639 - 12647 (2019/10/11)
A metal-free three-component annulation reaction for the synthesis of indolizine thiones via tandem C-C/C-N/C-S bond formation was developed. Various 2-alkylpyridines with aromatic ynals and elemental sulfur proceeded smoothly under catalyst-free conditions, and the desired products were obtained in moderate to excellent yields.
Palladium-Catalyzed Nitrile-Assisted C(sp3)-Cl Bond Formation for Synthesis of Dichlorides
He, Dandan,Huang, Liangbin,Li, Jianxiao,Wu, Wanqing,Jiang, Huanfeng
supporting information, p. 8308 - 8311 (2019/10/16)
A palladium-catalyzed coupling procedure of alkenes with alkynylnitriles has been demonstrated for the synthesis of dichlorides. The reaction is the first example of nitrile-assisted C(sp3)-Cl formation promoted by coordination of a cyano group with an alkylpalladium(II) complex. The construction of a five-membered cycle intermediate successfully inhibits the β-hydride abstraction, resulting in direct C-Cl bond reductive elimination of alkylpalladium(II) chloride.
Cascade reaction including a formal [5?+?2] cycloaddition by use of alkyne-Co2(CO)6 complex
Sakata, Yuki,Yasui, Eiko,Mizukami, Megumi,Nagumo, Shinji
supporting information, p. 755 - 759 (2019/02/20)
A new cascade reaction including formal [5 + 2] cycloaddition was developed. Treatment of homocinnamyl alcohol and Co2(CO)6-complexed arylpropynal with BF3·OEt2 resulted in the generation of hydrobenzocyclohepta
Cobalt-catalyzed (Z)-selective semihydrogenation of alkynes with molecular hydrogen
Chen, Caiyou,Huang, Yi,Zhang, Zongpeng,Dong, Xiu-Qin,Zhang, Xumu
supporting information, p. 4612 - 4615 (2017/04/28)
Cobalt-catalyzed highly (Z)-selective semihydrogenation of alkynes using molecular H2 was developed using commercially available and cheap cobalt precursors. A variety of (Z)-alkenes were obtained in moderate to excellent selectivities [(Z)-alkene/(E)-alkene/alkane ratio up to >99 : 1 : 1] and it was found that the readily available ethylenediamine ligand is crucial in determining the selectivity.
Squaramide catalyzed enantioselective iodolactonization of allenoic acids
Kristianslund, Renate,Aursnes, Marius,Tungen, J?rn Eivind,Hansen, Trond Vidar
supporting information, p. 5232 - 5236 (2016/11/13)
An asymmetric iodolactonization reaction of allenoic acids has been extensively studied. Eight different chiral squaramides were prepared in a straightforward manner and investigated as organocatalysts. The reaction protocol is operationally simple to exe
Pd(ii)-catalyzed formal [4+1] cycloaddition reactions of diazoacetates and aryl propargyl alcohols to form 2,5-dihydrofurans
Shi, Taoda,Guo, Xin,Teng, Shenghan,Hu, Wenhao
supporting information, p. 15204 - 15207 (2015/10/12)
A Pd(ii)-catalyzed formal [4+1] cycloaddition of aryl diazoacetates and aryl propargyl alcohols is reported to afford 2,5-dihydrofuran derivatives as the dominant product over other traditional ones. The auto-tandem catalytic process is proposed to occur via Pd(ii)-catalyzed intermolecular oxonium ylide formation and subsequent intramolecular trapping of the ylide with Pd(ii)-activated alkynes.
Iron-catalyzed reductive cyclization of 1,6-enynes
Lin, Aijun,Zhang, Zhi-Wei,Yang, Jiong
supporting information, p. 386 - 389 (2014/04/03)
A precatalyst of FeCl2 and iminopyridine was activated in situ by a combination of diethylzinc and magnesium bromide etherate; it catalyzed the reductive cyclization of 1,6-enynes to give pyrrolidine and tetrahydrofuran derivatives from N-and O
Substituent-dependent, iron-mediated tandem cyclization of diynes with benzaldehyde acetals to form highly functionalized indene derivatives
Xu, Tongyu,Yang, Qin,Ye, Wenjing,Jiang, Quanbin,Xu, Zhaoqing,Chen, Jiping,Yu, Zhengkun
supporting information; experimental part, p. 10547 - 10551 (2011/11/05)
A three-ring circus: The FeCl3-and FeBr3-mediated tandem cyclization of diynes with diethyl benzaldehyde acetals to form fused tricyclic indenes has been accomplished (see scheme). The consecutive formation of three new C-C bonds all
AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF
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Page/Page column 85, (2010/04/25)
Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of, for example, bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof. wherein each symbol is as defined in the specification.
