635757-93-6Relevant academic research and scientific papers
Ring-closing metathesis of fluoroalkenes toward the synthesis of fluorinated heterocycles containing an oxaza bond
Guérin, David,Dez, Isabelle,Gaumont, Annie-Claude,Pannecoucke, Xavier,Couve-Bonnaire, Samuel
, p. 740 - 748 (2017/11/13)
This study reports the ring-closing metathesis reaction of bisolefins, including a reluctant fluoroalkenes, linked with oxaza moiety. The resulting heterocycles were produced in high yields under high diluting conditions disfavoring the homodimerization s
New and concise syntheses of the bicyclic oxamazin core using an intramolecular nitroso diels-alder reaction and ring-closing olefin metathesis
Watson, Kyle D.,Carosso, Serena,Miller, Marvin J.
, p. 358 - 361 (2013/03/13)
Herein two new and concise synthetic approaches for making an unsaturated bicyclic oxamazin core are reported. The first involves the use of an intramolecular Diels-Alder reaction to form both of the fused rings in one step. The second approach incorporates ring-closing olefin metathesis in the final step to form the second fused ring of the core. The scope of the second approach was also expanded further to afford larger ringed bicyclic systems.
Influence of hydroxylamine conformation on stereocontrol in Pd-catalyzed isoxazolidine-forming reactions
Lernen, Georgia S.,Giampietro, Natalie C.,Hay, Michael B.,Wolfe, John P.
supporting information; experimental part, p. 2533 - 2540 (2009/08/07)
Palladium-catalyzed carboamination reactions between N-Boc-O-(but-3-enyl) hydroxylamine derivatives and aryl or alkenyl bromides afford cis-3,5- and trans-4,5-disubstituted isoxazolidines in good yield with up to >20:1 dr. The diastereoselectivity observe
Synthesis of a homologous series of side-chain-extended orthogonally protected aminooxy-containing amino acids
Liu, Fa,Thomas, Joshua,Burke Jr., Terrence R.
experimental part, p. 2432 - 2438 (2009/04/11)
Practical methodology is reported for the synthesis of a homologous series of side-chain-extended amino acids containing aminooxy functionality bearing orthogonal protection suitable for Fmoc peptide synthesis. These reagents may be useful for the preparation of libraries containing fragments joined by peptide linkers. Georg Thieme Verlag Stuttgart.
A versatile radical based approach to O-alkylated hydroxylamines and oximes
Quiclet-Sire, Béatrice,Woollaston, Daniel,Zard, Samir Z.
body text, p. 11917 - 11924 (2009/04/06)
O-Alkylhydroxylamines, often used for the preparation of bioconjugates, can be readily obtained by radical addition to suitable O-alkenylhydroxylamine derivatives. In the case of N-Boc-O-allylhydroxylamine, the addition is unexpectedly followed by elimination resulting in an overall allylation of the radical species.
Synthesis of heterocycles containing an N-O bond by ring-closing metathesis of dienes tethered by hydroxylamine
Yang, Young-Keun,Tae, Jinsung
, p. 1043 - 1045 (2007/10/03)
The dienes tethered by hydroxylamine were efficiently cyclized into 6- to 10-membered heterocycles containing an N-O bond by catalytic ring-closing metathesis.
Ring-Closing Metathesis of Enynes Tethered by an N-O Bond: Synthesis of 1,2-Oxaza Polycycles by Diels-Alder Reaction of the Ring-Closing Metathesis Products
Yang, Young-Keun,Tae, Jinsung
, p. 2017 - 2020 (2007/10/03)
Ring-closing metathesis (RCM) reaction of enynes tethered by an N-O bond produced 6- to 8-membered 1,2-oxaza heterocyclic compounds in high yields. Diels-Alder reaction of the cyclic 1,3-dienes with various dienophiles afforded bi- or tri-cyclic compounds
