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4-[(9-ethyl-9H-carbazol-3-yl)amino]phenol, also known as PR-619, is a chemical compound belonging to the phenol class. It is characterized by its potent and selective inhibition of the deubiquitinating enzyme (DUB) family, which are essential in protein degradation and turnover regulation within cells. The unique carbazole group in its structure makes PR-619 a promising candidate for therapeutic development, particularly in targeting DUBs. It has demonstrated potential as both an anti-inflammatory and anticancer agent in preclinical studies, with ongoing research to elucidate its full biological activities and therapeutic potential.

6358-26-5

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6358-26-5 Usage

Uses

Used in Research Studies:
4-[(9-ethyl-9H-carbazol-3-yl)amino]phenol is used as a research tool for investigating the role of DUBs in various cellular processes such as DNA damage response, inflammation, and cancer development. Its selectivity and potency make it a valuable asset in understanding the mechanisms of these processes and identifying potential therapeutic targets.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 4-[(9-ethyl-9H-carbazol-3-yl)amino]phenol is used as a lead compound for the development of new therapeutics targeting DUBs. Its unique structure and demonstrated biological activities suggest its potential in creating innovative treatments for various diseases, particularly those involving abnormal protein regulation.
Used in Anti-inflammatory Applications:
4-[(9-ethyl-9H-carbazol-3-yl)amino]phenol is used as an anti-inflammatory agent in preclinical studies, where it has shown promise in reducing inflammation. Its ability to modulate the activity of DUBs, which are involved in inflammatory pathways, positions it as a potential treatment for inflammatory disorders.
Used in Anticancer Applications:
In oncology, 4-[(9-ethyl-9H-carbazol-3-yl)amino]phenol is used as a potential anticancer agent. Its demonstrated effects in preclinical studies suggest that it could be a valuable component in cancer treatment strategies, particularly for cancers where DUB activity is implicated in tumor progression and resistance to therapy.
Further research is necessary to fully understand the breadth of 4-[(9-ethyl-9H-carbazol-3-yl)amino]phenol's applications and to optimize its use in various therapeutic areas.

Check Digit Verification of cas no

The CAS Registry Mumber 6358-26-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,5 and 8 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 6358-26:
(6*6)+(5*3)+(4*5)+(3*8)+(2*2)+(1*6)=105
105 % 10 = 5
So 6358-26-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H18N2O/c1-2-22-19-6-4-3-5-17(19)18-13-15(9-12-20(18)22)21-14-7-10-16(23)11-8-14/h3-13,21,23H,2H2,1H3

6358-26-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[(9-ethyl-9H-carbazol-3-yl)amino]phenol

1.2 Other means of identification

Product number -
Other names Phenol,p-((9-ethylcarbazol-3-yl)amino)-(8ci)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6358-26-5 SDS

6358-26-5Downstream Products

6358-26-5Relevant academic research and scientific papers

Process for the preparation of derivatives of 3-(4-hydroxy-anilino)carbazole

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, (2008/06/13)

The process for the preparation of a 3-(4-hydroxyanilino)carbazole of the formula STR1 wherein R is hydrogen, alkyl having 1 to 8 carbon atoms or halogenoalkyl having 1 to 8 carbon atoms, comprising reacting a 3-aminocarbazole of the formula STR2 with p-hydroquinone or p-aminophenol or a mixture of p-hydroquinone and p-aminophenol in at least stoichiometric amounts by heating to a temperature of 150° to 300° C. with exclusion of oxygen.

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