63581-34-0

Basic information

• Product Name: 2-amino-3-(p-methoxybenzylideneamino)pyridine
• Synonyms: 2-amino-3-(p-methoxybenzylideneamino)pyridine
• CAS NO: 63581-34-0
• Molecular Weight: 227.266
• Mol File: 63581-34-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-amino-3-(p-methoxybenzylideneamino)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-3-(p-methoxybenzylideneamino)pyridine(63581-34-0)
• EPA Substance Registry System: 2-amino-3-(p-methoxybenzylideneamino)pyridine(63581-34-0)

Safety Data

• Hazardous Substances Data: 63581-34-0(Hazardous Substances Data)

Upstream product

• 452-58-4 2,3-Diaminopyridine 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 63581-47-5 2-(4-methoxy-phenyl)-1⁽³⁾H-imidazo[4,5-b]pyridine 

Relevant articles and documents

Synthesis and antiproliferative activity in vitro of new 2-thioxoimidazo[4,5-b]pyridine derivatives

Two series of 2-thioxoimidazo[4,5-b]pyridine derivatives have been synthesized from 2,3-diaminopyridine (1) and 5-halogenosubstituted-2,3-diaminopyridines 2, 3. Mannich bases 7 - 12 and 24 - 29, derivatives of 1-arylamino-6-halogeno-2-thioxoimidazo[4,5-b]pyridine were obtained with selected secondary amines: morpholine, piperidine, 2-methoxyphenylpiperazine, pyrimidyn-2-yl-piperazine and formaldehyde in ethanol. The structures 7 - 12 and 24 - 29 were confirmed by the results of elementary analysis and their IR,1H-NMR and MS spectra. All given structures 7 - 12 have been optimized to get the most stable low energy conformers. Synthesized compounds were of interest for biological studies or can be substrates for further synthesis. The selected compounds 7 - 10, 12 - 17, 22, 25, 27 - 29 were screened for their antiproliferative activity in vitro against human cancer and normal mouse fibroblast cell lines.