63586-33-4

Basic information

• Product Name: 6-Chloro-2-Methyl-5-nitropyriMidin-4-aMine
• Synonyms: 6-Chloro-2-Methyl-5-nitropyriMidin-4-aMine
• CAS NO: 63586-33-4
• Molecular Formula: C5H5ClN4O2
• Molecular Weight: 188.5718
• Mol File: 63586-33-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Chloro-2-Methyl-5-nitropyriMidin-4-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-2-Methyl-5-nitropyriMidin-4-aMine(63586-33-4)
• EPA Substance Registry System: 6-Chloro-2-Methyl-5-nitropyriMidin-4-aMine(63586-33-4)

Safety Data

• Hazardous Substances Data: 63586-33-4(Hazardous Substances Data)

Usage

General Description

6-Chloro-2-Methyl-5-nitropyrimidin-4-amine, also known as CSCVCPADMB or under the CAS Number 884494-52-4, is a chemical compound that belongs to the class of organic compounds called aminopyrimidines and derivatives. It involves a pyrimidine ring which is an aromatic and dicarbocyclic compound bearing an amino group. It has the molecular formula C5H5ClN4O2. With a molecular weight of 192.57, it is moderately polar and has a good stability, making it suitable for storage under regular conditions. Most commonly, it is used as a reagent in the synthesis of other chemicals in laboratory or industrial settings. Its hazard statements are yet to be identified since extensive research and studies are required for in-depth understanding of the properties and potential risks.

Upstream product

• 13162-43-1 4,6-dichloro-2-methyl-5-nitropyrimidine 
• 17551-52-9 2-methyl-4-hydroxy-6-chloropyrimidine 
• 82779-50-8 4,6-dichloro-2-methyl-5-nitropyrimidine 
• 631-61-8 ammonium acetate 

Downstream Products

• 15579-63-2 2-methyl-pyrimidine-4,5-diyldiamine 
• 2432-20-4 2-methyl-pteridine 
• 23767-00-2 2,6,7-Trimethyl-pteridin 

Relevant articles and documents

Discovery of 5-Nitro-6-thiocyanatopyrimidines as Inhibitors of Cryptococcus neoformans and Cryptococcus gattii

Opportunistic infections from pathogenic fungi present a major challenge to healthcare because of a very limited arsenal of antifungal drugs, an increasing population of immunosuppressed patients, and increased prevalence of resistant clinical strains due to overuse of the few available antifungals. Cryptococcal meningitis is a life-threatening opportunistic fungal infection caused by one of two species in the Cryptococcus genus, Cryptococcus neoformans and Cryptococcus gattii. Eighty percent of cryptococcosis diseases are caused by C. neoformans that is endemic in the environment. The standard of care is limited to old antifungals, and under a high standard of care, mortality remains between 10 and 30%. We have identified a series of 5-nitro-6-thiocyanatopyrimidine antifungal drug candidates using in vitro and computational machine learning approaches. These compounds can inhibit C. neoformans growth at submicromolar levels, are effective against fluconazole-resistant C. neoformans and a clinical strain of C. gattii, and are not antagonistic with currently approved antifungals.