63599-98-4Relevant articles and documents
Synthesis and cytotoxicity of Methyl-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione derivatives
Chao, Yu-Hua,Kuo, Sheng-Chu,Ku, Kelvin,Chiu, I-Ping,Wu, Chun-Hsiung,Mauger, Anthony,Wang, Hui-Kang,Lee, Kuo-Hsiung
, p. 1025 - 1031 (2007/10/03)
2- and 3-Methyl-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione and related derivatives were synthesized and evaluated in vitro by NCI against eight cancer types. Compounds 12-15 showed significant activity against melanoma, NCI-H23 non-small cell lung cancer, and MDA-MB-435 and MDA-N breast cancer cell lines; 2-hydroxymethyl-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione (13) showed the highest activity against melanoma (mean log GI50=-7.74) and the highest overall potency (mean log GI50=-6.99). Copyright (C) 1999 Published by Elsevier Science Ltd.