63599-98-4Relevant academic research and scientific papers
Synthesis and cytotoxicity of Methyl-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione derivatives
Chao, Yu-Hua,Kuo, Sheng-Chu,Ku, Kelvin,Chiu, I-Ping,Wu, Chun-Hsiung,Mauger, Anthony,Wang, Hui-Kang,Lee, Kuo-Hsiung
, p. 1025 - 1031 (2007/10/03)
2- and 3-Methyl-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione and related derivatives were synthesized and evaluated in vitro by NCI against eight cancer types. Compounds 12-15 showed significant activity against melanoma, NCI-H23 non-small cell lung cancer, and MDA-MB-435 and MDA-N breast cancer cell lines; 2-hydroxymethyl-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione (13) showed the highest activity against melanoma (mean log GI50=-7.74) and the highest overall potency (mean log GI50=-6.99). Copyright (C) 1999 Published by Elsevier Science Ltd.
Synthesis of Thiophenedicarbonyldiazides and Di-t-butyl Thiophendicarbamates
Galvez, Carmen,Garcia, Francisco,Garcia, Juan,Soldevila, Joan
, p. 1103 - 1108 (2007/10/02)
Dicarbamates 1b and 1c, and dicarbonyldiazides 2b and 2c are obtained in good yields starting from thiophenedicarboxylic acids 3b and 3c, but the vicinal diacids 3a and 3d are not suitable for the synthesis of dicarbamates 1a and 1d and dicarbonyldiazides 2a and 2d; 1a is prepared by a stepway procedure previously described, and 1d by t-butoxycarbonylation of the recently known 3,4-thiophenediamine.
