636-00-0

Basic information

• Product Name: 6-HYDROXYDOPAMINE HYDROBROMIDE
• Synonyms: 1,2,4-Benzenetriol,5-(2-aminoethyl)-, hydrobromide (1:1);2-(2,4,5-TRIHYDROXYPHENYL)ETHYLAMINE HYDROBROMIDE;2,5-DIHYDROXYTYRAMINE HYDROBROMIDE;2,4,5-TRIHYDROXYPHENETHYLAMINE HYDROBROMIDE;6-HYDROXYDOPAMINE HBR;6-HYDROXYDOPAMINE HYDROBROMIDE;2,4-benzenetriol,5-(2-aminoethyl)-hydrobromide;2,4,5-Trihydroxyphenethylamine
• CAS NO: 636-00-0
• Molecular Formula: BrH*C₈H₁₁NO₃
• Molecular Weight: 250.09
• EINECS: 211-247-0
• Product Categories: Dopamine receptor;Amino Alcohols;Bioactive Small Molecules;Building Blocks;Cell Biology;Chemical Synthesis;H;Organic Building Blocks;Oxygen Compounds
• Mol File: 636-00-0.mol

Chemical Properties

• Melting Point: 216-220 °C(lit.)
• Boiling Point: 406oC at 760 mmHg
• Flash Point: 199.3oC
• Appearance: tan to brown/solid
• Vapor Pressure: 3.58E-07mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• Stability: Hygroscopic, Light Sensitive
• BRN: 3713280
• CAS DataBase Reference: 6-HYDROXYDOPAMINE HYDROBROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-HYDROXYDOPAMINE HYDROBROMIDE(636-00-0)
• EPA Substance Registry System: 6-HYDROXYDOPAMINE HYDROBROMIDE(636-00-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: DC4600000
• F: 3-10
• Hazardous Substances Data: 636-00-0(Hazardous Substances Data)

Usage

Uses

Used in Neuroscience Research:
6-Hydroxydopamine hydrobromide is used as a neurotoxin for creating animal models of Parkinson's disease, as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. This helps researchers study the progression of the disease and test potential treatments.
Used in Cellular and Molecular Studies:
6-Hydroxydopamine hydrobromide is used as an inducer of apoptosis in PC12 cells, a rat adrenal pheochromocytoma cell line commonly used in neurobiological research. This application aids in understanding the mechanisms of cell death and the effects of various interventions on neuronal survival.
Used in Investigating Neurotransmitter Systems:
6-Hydroxydopamine hydrobromide is used to study the effects of dopamine and norepinephrine depletion in the brain. By administering the neurotoxin intracisternally at specific doses, researchers can investigate the role of these neurotransmitters in various brain functions and disorders.
Used in Drug Development:
6-Hydroxydopamine hydrobromide serves as a valuable tool in the development of drugs targeting neurodegenerative diseases, particularly Parkinson's disease. By using this neurotoxin to create animal models, researchers can evaluate the efficacy and safety of potential therapeutic agents in treating or preventing the disease.

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