63603-10-1Relevant articles and documents
MACROCYCLIC DIAMINE DERIVATIVES AS ENT INHIBITORS FOR THE TREATMENT OF CANCERS, AND COMBINATION THEREOF WITH ADENOSINE RECEPTOR ANTAGONISTS
-
Paragraph 0486; 0554, (2021/10/15)
The present invention relates to macrocyclic diamine derivatives of formula II, including pharmaceutically acceptable salts and solvates thereof. Compounds of the invention are inhibitors of ENT family transporter, especially of ENT1, and are useful as therapeutic compounds for the treatment of cancers. The invention also relates to the combined use of the macrocyclic diamine derivatives with an adenosine receptor antagonist, for the treatment of cancers.
FUSED PYRIMIDINOPIPERIDINE DERIVATIVE, AND MANUFACTURING METHOD AND APPLICATION THEREOF
-
, (2019/04/25)
The present invention relates to the fused pyrimidine piperidine cyclic derivative represented by the following formula (I) and a pharmaceutically acceptable salt thereof and a process for preparing the same, wherein R1, R2, R3
Therapeutic Aryl-Amido-Aryl Compounds and Their Use
-
, (2012/06/18)
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-amido-aryl compounds of the following formula (for convenience, collectively referred to herein as “AAA compounds”), which, inter alia, a
THERAPEUTIC ARYL-AM I DO-ARYL COMPOUNDS AND THEIR USE
-
, (2011/04/14)
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-amido-aryl compounds of the following formula (for convenience, collectively referred to herein as "AAA compounds"), which, inter alia, a
Formal total synthesis of N-methylmaysenine
Wang, Lin,Gong, Jianxian,Deng, Lujiang,Xiang, Zheng,Chen, Zhixing,Wang, Yuefan,Chen, Jiahua,Yang, Zhen
supporting information; experimental part, p. 1809 - 1812 (2009/09/06)
A novel synthetic approach for the formal total synthesis of N-methylmaysenine (1) has been developed. Key steps Involve the Ti-mediated vlnylogous Mukaiyama aldol reaction of chlral ketene silyl N,O-acetal with β-dithiane-substituted aldehyde, an aldol c