63614-65-3Relevant academic research and scientific papers
Synthesis of 1H-1,5-benzodiazepin-2(3H)-ones from 5(4H)-isoxazolone, a heterocyclic bifunctional C-3 synthon
Rao,Reddy,Veeranagaiah
, p. 446 - 448 (2007/10/02)
Unsubstituted and 7- or 8-substituted 4-aryl-1H-1,5-benzodiazepin-2(3H)-ones 3a-t have been synthesized by the condensation of 3-aryl-5(4H)-isoxazolones 1a-e and parent 4-substituted 1,2-benzenediamines 2a-d under acidic conditions.
SYNTHESIS OF 1,5-BENZODIAZEPINES
Ushirogochi, Atsuyuki,Tominaga, Yoshinori,Matsuda, Yoshiro,Kobayashi, Goro
, p. 7 - 10 (2007/10/02)
Reaction of α-oxoketene S,S-acetals (1a, b, c, d) with o-phenylenediamines gave the corresponding 1,5-benzodiazepines, 8-substituted 4-aryl-2-methylthio-3H-1,5-benzodiazepines (3a, b, c, d, e) in good yields. 2-Amino-4-aryl-8-nitro-3H-1,5-benzodiazepines (5a, b, c) were prepared by the displacement of methylthio group on compound 3b with amines (benzylamine, morpholine, 1-methylpiperazine).
