63631-11-8Relevant articles and documents
N3-Arylmalonamides: A new series of thieno[3,2-b]pyridine based inhibitors of c-Met and VEGFR2 tyrosine kinases
Saavedra, Oscar,Claridge, Stephen,Zhan, Lijie,Raeppel, Franck,Granger, Marie-Claude,Raeppel, Stéphane,Mannion, Michael,Gaudette, Frédéric,Zhou, Nancy,Isakovic, Ljubomir,Bernstein, Naomy,Déziel, Robert,Nguyen, Hannah,Beaulieu, Normand,Beaulieu, Carole,Dupont, Isabelle,Wang, James,Macleod, A. Robert,Besterman, Jeffrey M.,Vaisburg, Arkadii
scheme or table, p. 6836 - 6839 (2010/06/19)
A family of thieno[3,2-b]pyridine based small molecule inhibitors of c-Met and VEGFR2 were designed based on lead structure 2. These compounds were shown to have IC50 values in the low nanomolar range in vitro and were efficacious in human tumo
