63631-33-4Relevant academic research and scientific papers
5-(1H-benzotriazol-1-yloxy)-3,4-dihydro-1-methyl 2H-pyrrolium hexachloroantimonate (BDMP): A highly efficient immonium type peptide coupling reagent
Li, Peng,Xu, Jie Cheng
, p. 1163 - 1164 (2007/10/03)
HOBt-based immonium type coupling reagent, 5-(1H-benzotriazol-1-yloxy)-3,4-dihydro-1-methyl 2H-pyrrolium hexachloroantimonate (BDMP) has been designed, synthesized and utilized to synthesize oligopeptides and biologically active peptides both in solution
A new coupling reagent for peptide synthesis. Benzotriazolvyloxy-bis (pyrroltdino) -carbonium hexaflouorophosphate (BBC)
Chen, Shaoqing,Xu, Jiecheng
, p. 647 - 650 (2007/10/02)
Benzotriazolyloxy-bis(pyrrolidino)-carbonium hexa- fluorophosphate (BBC) is found to be a new excellent coupling reagent devoid of cytotoxic by-product instead of HBTU and BOP. It has been applied in the solution and solid phase peptide synthesis.
" Mediator Methodology" for the Synthesis of Peptides in a Two-Polymeric System
Shai, Yechiel,Jacobson, Kenneth A.,Patchornik, Abraham
, p. 4249 - 4252 (2007/10/02)
Abstract: A novel methodology is described for a potential automated self-controlled synthesis of peptides.The method is based on transferring an N-protected amino acid from one insoluble polymer (donor) such as a polymeric o-nitrophenyl ester (a "bank" of active ester) to an insoluble polymer-bound amino acid (acceptor),with the aid of a soluble mediator molecule (shadchan)2 The method gives high yields of pure peptides by garanteeing stoichiomeric supply of the active ester and allowing self monitoring.When the polymer-bound (dimethylamino)pyridinium salts, the condensation reaction was expended to also include sulfonation and particularly phosphorylation reactions.
