69472-91-9

Upstream product

• 57729-52-9 tert-Butoxycarbonyl-O-benzyl-L-tyrosyl-glycyl-glycin-methylester 
• 87423-40-3 Boc-Tyr(OBzl)-Gly-Gly-OEt 
• 56-40-6 glycine 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 

Downstream Products

• 61131-31-5 Boc-Tyr(Bzl)-Gly-Gly-Phe-Leu-OH 
• 58569-54-3 tert-Butoxycarbonyl-o-benzyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-methionin-methylester 
• 63631-33-4 Boc-Tyr(OBz)-Gly-Gly-Phe-Leu-OCH₃ 
• 88621-27-6 Boc-Tyr(Bzl)-Gly-Gly-Phet-Leu-OBzl 
• 81638-88-2 amide of N-t-butyloxycarbonyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine 
• 252846-44-9 Boc-L-Tyr(Bzl)-Gly-Gly-L-Phe-O-carbamoylmethyl 
• 1025072-79-0 C₄₀H₅₁N₉O₇ 
• 88621-28-7 H-Tyr-Gly-Gly-Phet-Leu-OH 
• 126028-16-8 Boc-L-Tyr-Gly-Gly-L-Phe-OCam 
• 79396-86-4 Boc-L-Tyr-Gly-Gly-L-Phe-L-Leu-NH₂ 

Relevant academic research and scientific papers

Syntheses of Fmoc-α-aminoalkyltetrazoles and tetrazole analogue of Leu-enkephalin

Five Fmoc-α-aminoalkyltetrazoles were synthesized starting from Fmoc-α-amino acids. Fmoc-LeuT was applied in synthesis of tetrazole analogue of Leu-enkephalin by solid phase peptide synthesis (SPPS), as well as in solution. Radioreceptor assays showed hig

An Effective Water-Free Aprotic System for Dissolving Free Amino Acids

An effective water-free system was proposed for dissolution and subsequent use in peptide synthesis of free amino acids and their derivatives. It consists of dimethylformamide, a tertiary base, and inorganic additives. Neutral salts (CF3COONa, Ba(ClO4)2, Ca(ClO4)2, NaClO4, BaI2, or Ca(NO3)2) serve as the inorganic additives that increase the solubility of free amino acids in dimethylformamide and provide true 0.2-3 M amino acid solutions. Triethylamine and N-methylmorpholine are most suitable as the tertiary bases. This system was used in reactions with acylating agents: Boc2O, ZOSu, FmocOSu, and activated derivatives of Nα-protected amino acids or peptides. The corresponding amino acid derivatives or Nα-protected di-, tri-, and tetrapeptides were obtained in yields of 80-99 percent at the reaction times of 30-240 min.

Studies on Amino Acids and Peptides. Part 6. Methods for Introducing Thioamide Bonds into the Peptide Backbone: Synthesis of the Four Monothio Analogues of Leucine Enkephalin

A methodology for preparing peptide analogues in which a thioamide bond replaces the normal amide bond is described.Thus, the synthesis of the three leucine enkephalin analogues 4>-, 2>-, and 1>-leucine enke