63650-49-7

Upstream product

• 155-12-4 2-chloro-5-fluoropyrimidine-4(3H)-one 
• 71-36-3 butan-1-ol 
• 2927-71-1 2,4-dichloro-5-fluoropyrimidine 
• 155-12-4 2-chloro-5-fluoro-4(1H)-pyrimidone 
• 40423-64-1 2,4-dibutoxy-5-fluoropyrimidine 

Downstream Products

• 1398662-57-1 C₁₄H₁₄ClF₂N₃O 
• 1398662-60-6 C₁₅H₁₅F₄N₃O 
• 1398662-62-8 C₁₄H₁₅ClFN₃O 
• 1398662-65-1 C₁₄H₁₅BrFN₃O 
• 1398662-27-5 C₁₄H₁₆FN₃O 
• 1398662-86-6 C₁₄H₂₂FN₃O 
• 1398662-33-3 C₁₆H₂₀FN₃O 
• 1398662-38-8 C₁₅H₁₈FN₃O₂ 
• 1398662-42-4 C₁₅H₁₈FN₃O 
• 1398662-48-0 C₁₄H₁₅ClFN₃O 
• 1398662-51-5 C₁₅H₁₈FN₃O 
• 1398662-54-8 C₁₄H₁₄Cl₂FN₃O 

Relevant academic research and scientific papers

Novel 5-fluorouracil derivatives: Synthesis and cytotoxic activity of 2-butoxy-4-substituted 5-fluoropyrimidines

Twenty two new 5-fluorouracil (5-FU) derivatives, 2-butoxy-4-substituted 5-fluoropyrimidines, were synthesized and characterized by IR, 1H NMR, MS, HRMS. All compounds were preliminarily evaluated by MTT assay on human liver BEL-7402 cancer cell line in vitro. Ten compounds were selected to test their cytotoxic activity against A549, HL-60 and MCF-7 cancer cell lines in vitro. These compounds were more sensitive to BEL-7402 than other cell lines, particularly, cytotoxic activity of compounds 6b, 6d-f, 6p, 6s-u were in sub-micromolar scale. The highest cytotoxic potency against A549, HL-60 and MCF-7 was shown by 2-butoxy-4-chloro-5- fluoropyrimidine (5) with IC 50 values of 0.10, 1.66 and 0.59 μM, respectively. Compounds 6d and 6e were effective against MCF-7 with IC50 9.73 μM and HL-60 with IC50 8.83 μM, respectively.

5-Fluoropyrimidin-4-one compositions

A 5-fluoropyrimidin-4-one derivative represented by the formula STR1 wherein R is straight-chain or branched-chain alkyl having 4 to 18 carbon atoms, straight-chain or branched-chain alkenyl having 2 to 18 carbon atoms, alkylene oxido having 3 to 10 carbon atoms, aryl or aralkyl; Processes for preparing the derivative; An anti-tumor composition containing the derivative as an effective component and an excipient.