63650-60-2Relevant academic research and scientific papers
PROCESS FOR PRODUCTION OF 5-ALKOXY-4-HYDROXYMETHYLPYRAZOLE COMPOUND
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Page/Page column 12, (2008/12/08)
The present invention relates to a process for producing a 5-alkoxy-4-hydroxymethylpyrazole compound in a simple manner and with good efficiency. A process for producing a 5-alkoxy-4-hydroxymethylpyrazole compound represented by the general formula (3) which comprises reacting a pyrazole compound represented by the general formula (1) (wherein R1 is a substituent such as alkyl group, substituted or unsubstituted group or the like, and R2 is an electron withdrawing group) with a compound represented by the general formula (2) ????????L-R3?????(2) (wherein L is a leaving group and R3 is a substituent such as substituted or unsubstituted alkyl group or the like) in the presence of a base and formaldehyde.
PROCESS FOR PRODUCING 5-HYDROXY-4-THIOMETHYLPYRAZOLE COMPOUND
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Page/Page column 12, (2008/06/13)
A pyrazole compound represented by general formula (1) is reacted with a sulfur compound represented by general formula (2) in the presence of a base and formaldehyde, to thereby produce a 5-hydroxy-4-thiomethylpyrazole compound represented by general formula (3). The 5-hydroxy-4-thiomethylpyrazole compound may easily be produced in a good yield, by using such a process. Further, this process may easily provide the 5-hydroxy-4-thiomethylpyrazole compound under a mild condition in a single step, without using a special apparatus, an expensive catalyst, or a transition metal, etc. In addition, this process may be conducted substantially without producing a harmful waste which can be derived from a catalyst, etc., and therefore this process is friendly to the environment and industrially valuable.
