636567-58-3

Basic information

• Product Name: N,N-bis(methylsulfonyl)-2-iodoaniline
• Synonyms: N,N-bis(methylsulfonyl)-2-iodoaniline
• CAS NO: 636567-58-3
• Molecular Weight: 375.208
• Mol File: 636567-58-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N,N-bis(methylsulfonyl)-2-iodoaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-bis(methylsulfonyl)-2-iodoaniline(636567-58-3)
• EPA Substance Registry System: N,N-bis(methylsulfonyl)-2-iodoaniline(636567-58-3)

Safety Data

• Hazardous Substances Data: 636567-58-3(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 615-43-0 2-iodophenylamine 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 365224-31-3 1-methanesulfonyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-1H-indole 
• 592466-64-3 1-methanesulfonyl-2-[4-(2-methoxy-ethoxymethoxy)-phenyl]-1H-indole 
• 365224-47-1 4-(1-methanesulfonyl-1H-indol-2-yl)-phenol 
• 116547-92-3 N-(2-iodophenyl)methanesulfonamide 

Relevant articles and documents

A bioisosteric approach to the discovery of indole carbinol androgen receptor ligands

Two potential bioisosteres of the nonsteroidal antiandrogen bicalutamide, an imidazolidinone and an indole, were synthesized and tested for their androgen receptor binding. Indole was discovered to be a suitable bioisostere for the acyl anilide moiety in the parent compound. Several analogs in the indole series were found to be 10-fold better than bicalutamide in binding to the recombinant androgen receptor binding domain.

Novel indole derivatives as selective androgen receptor modulators (SARMS)

The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

Non-imidazole heterocyclic histamine H3 receptor antagonists

Continued exploration of the SAR around the lead imidazopyridine histamine H3 antagonist 1 has led to the discovery of several related series of heterocyclic histamine H3 antagonists. The synthesis and SAR of indolizine, indole and p