636572-25-3

Basic information

• Product Name: (2E,17E)-(7S,22S)-8,23-Dibenzyl-7,22-diisopropyl-5,20-dioxa-8,23-diaza-tricyclo[26.2.2.2^13,16]tetratriaconta-1⁽³¹⁾,2,13⁽³⁴⁾,14,16⁽³³⁾,17,28⁽³²⁾,29-octaene-4,19-dione
• Synonyms: (2E,17E)-(7S,22S)-8,23-Dibenzyl-7,22-diisopropyl-5,20-dioxa-8,23-diaza-tricyclo[26.2.2.2^13,16]tetratriaconta-1⁽³¹⁾,2,13⁽³⁴⁾,14,16⁽³³⁾,17,28⁽³²⁾,29-octaene-4,19-dione
• CAS NO: 636572-25-3
• Molecular Weight: 755.053
• Mol File: 636572-25-3.mol

Chemical Properties

• CAS DataBase Reference: (2E,17E)-(7S,22S)-8,23-Dibenzyl-7,22-diisopropyl-5,20-dioxa-8,23-diaza-tricyclo[26.2.2.2^13,16]tetratriaconta-1⁽³¹⁾,2,13⁽³⁴⁾,14,16⁽³³⁾,17,28⁽³²⁾,29-octaene-4,19-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (2E,17E)-(7S,22S)-8,23-Dibenzyl-7,22-diisopropyl-5,20-dioxa-8,23-diaza-tricyclo[26.2.2.2^13,16]tetratriaconta-1⁽³¹⁾,2,13⁽³⁴⁾,14,16⁽³³⁾,17,28⁽³²⁾,29-octaene-4,19-dione(636572-25-3)
• EPA Substance Registry System: (2E,17E)-(7S,22S)-8,23-Dibenzyl-7,22-diisopropyl-5,20-dioxa-8,23-diaza-tricyclo[26.2.2.2^13,16]tetratriaconta-1⁽³¹⁾,2,13⁽³⁴⁾,14,16⁽³³⁾,17,28⁽³²⁾,29-octaene-4,19-dione(636572-25-3)

Safety Data

• Hazardous Substances Data: 636572-25-3(Hazardous Substances Data)

Upstream product

• 636572-20-8 (S)-2-{Benzyl-[4-(4-iodo-phenyl)-butyl]-amino}-3-methyl-butan-1-ol 
• 636572-19-5 (S)-2-[4-(4-Iodo-phenyl)-butylamino]-3-methyl-butan-1-ol 
• 374590-35-9 4-(4-iodophenyl)butyraldehyde 
• 2026-48-4 (S)-valinol 
• 636572-24-2 Acrylic acid (S)-2-{benzyl-[4-(4-iodo-phenyl)-butyl]-amino}-3-methyl-butyl ester 

Relevant articles and documents

A new class of non-racemic chiral macrocycles: A conformational and synthetic study

Amino alcohols have been used to introduce non-racemic chirality into macrocycles using a modular approach that relies on a Heck macrocyclisation reaction. A wide variety of macrocycles have been synthesised, and their structures studied using X-ray crystallography and molecular modelling. A fragmentation reaction encountered during the use of (S)-1,1-dimethylvalinol revealed that carboxylic acids generate acylals under reaction conditions often used for Heck reactions.

A versatile approach to chiral macrocycles

Head-to-tail Heck coupling of units derived from amino alcohols and iodoaryl aldehydes provides a short and versatile route to non-racemic chiral macrocycles.