374590-35-9

Upstream product

• 5435-06-3 4-methyl-N-[4-phenyl(4-deutero)butyl]benzene-1-sulfonamide 
• 627-27-0 homoalylic alcohol 
• 624-38-4 para-diiodobenzene 
• 756890-85-4 methyl 4-(4-iodophenyl)butanoate 
• 27913-58-2 4-(4-iodophenyl)butanoic acid 

Downstream Products

• 1215455-18-7 C₃₀H₃₄O₃ 
• 636572-25-3 (2E,17E)-(7S,22S)-8,23-Dibenzyl-7,22-diisopropyl-5,20-dioxa-8,23-diaza-tricyclo[26.2.2.2^13,16]tetratriaconta-1⁽³¹⁾,2,13⁽³⁴⁾,14,16⁽³³⁾,17,28⁽³²⁾,29-octaene-4,19-dione 
• 636572-22-0 2-((S)-2-{Benzyl-[4-(4-iodo-phenyl)-butyl]-amino}-3-methyl-butoxymethyl)-acrylic acid methyl ester 
• 636572-24-2 Acrylic acid (S)-2-{benzyl-[4-(4-iodo-phenyl)-butyl]-amino}-3-methyl-butyl ester 
• 636572-20-8 (S)-2-{Benzyl-[4-(4-iodo-phenyl)-butyl]-amino}-3-methyl-butan-1-ol 
• 636572-19-5 (S)-2-[4-(4-Iodo-phenyl)-butylamino]-3-methyl-butan-1-ol 

Relevant academic research and scientific papers

Iridium-catalyzed, diastereoselective dehydrogenative silylation of terminal alkenes with (TMSO)2MeSiH

Ligands' choice: The title reaction was achieved under mild conditions with low catalyst loading. The diastereoselectivity of the reaction can be controlled by choosing the appropriate ancillary ligand (see scheme; coe=cyclooctene). The silylation product

Click synthesis of estradiol-cyclodextrin conjugates as cell compartment selective estrogens

Cyclodextrin (CD) is a well known drug carrier and excipient for enhancing aqueous solubility. CDs themselves are anticipated to have low membrane permeability because of relatively high hydrophilicity and molecular weight. CD derivatization with 17-beta estradiol (E2) was explored extensively using a number of different click chemistries and the cell membrane permeability of synthetic CD-E2 conjugate was explored by cell reporter assays and confocal fluorescence microscopy. In simile with reported dendrimer-E2 conjugates, CD-E2 was found to be a stable, extranuclear receptor selective estrogen that penetrated into the cytoplasm.

Synthesis of meta- and paracyclophanes containing unsaturated amino acid residues

[7.7], [8.8], [9.9] and [13.13] Paracyclophanes and [9.9] and [13.13] metacyclophanes containing two unsaturated amino acid residues have been synthesised. An X-ray crystallographic study of three of the paracyclophanes and molecular modelling of two para

Oxidatively sonochemical dealkylation of various N-alkylsulfonamides to free sulfonamides and aldehydes

Various N-alkylsulfonamides were easily dealkylated to give the corresponding free sulfonamides in moderate to good yields in the presence of (diacetoxyiodo)benzene and iodine under ultrasonic irradiation. Application of this methodology to various N-prot