63660-21-9

Usage

Uses

Used in Pharmaceutical Industry:
5'-DMT-5-BROMO-DU PHOSPHORAMIDITE (CHIRAL) is used as a precursor in the synthesis of modified nucleic acids for the development of potential antivirals, antibacterials, antifungals, and antineoplastics. The unique properties of 5'-DMT-5-BROMO-DU PHOSPHORAMIDITE (CHIRAL), such as the bromine atom and the chiral center, allow for the creation of novel therapeutic agents with improved specificity and efficacy against various diseases.
In the development of antivirals, 5'-DMT-5-BROMO-DU PHOSPHORAMIDITE (CHIRAL) can be incorporated into oligonucleotides that target and inhibit the replication of viral genomes, thereby preventing the spread of viral infections.
In the context of antibacterial applications, 5'-DMT-5-BROMO-DU PHOSPHORAMIDITE (CHIRAL) can be used to create modified oligonucleotides that target and disrupt the function of essential bacterial genes, leading to the inhibition of bacterial growth and proliferation.
For antifungal purposes, 5'-DMT-5-BROMO-DU PHOSPHORAMIDITE (CHIRAL) can be utilized to design oligonucleotides that specifically target fungal RNA or DNA, thereby inhibiting fungal growth and reducing the severity of fungal infections.
In the field of antineoplastics, 5'-DMT-5-BROMO-DU PHOSPHORAMIDITE (CHIRAL) can be employed to synthesize modified nucleic acids that target cancer-related genes or pathways, leading to the suppression of tumor growth and the enhancement of cancer treatment outcomes.
Overall, 5'-DMT-5-BROMO-DU PHOSPHORAMIDITE (CHIRAL) is a versatile and essential compound in the pharmaceutical industry, playing a crucial role in the development of innovative therapeutic agents for various medical applications.

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 59-14-3 5-bromo-2'-deoxyuridine 
• 40615-35-8 4,4'-dimethoxytrityl alcohol 

Downstream Products

• 149725-98-4 5'-O-DMT-5-amino-2'-deoxyuridine 
• 908138-98-7 N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-furan-2-yl-propionamide 
• 1363720-95-9 3'-O-(tetra-butyldimethylsilyl)5'-O-(4,4'-dimethyoxytrityl)-N-acetyl-5-(dimethylamino)-2'-deoxyuridine 
• 1363720-96-0 ''3'-O-(tetra-butyldimethylsilyl)-5'-O-(4,4-dimethoxytrityl)5-dimethylamino-2'-deoxycytidine'' 
• 1363721-00-9 5'-O-(4,4'-dimethoxytrityl)-N-acetyl-5-dimethylamino-2-deoxycytidine 
• 1363720-98-2 3'-O-(tetra-butyldimethylsilyl)5'-O-(4,4'-dimethyoxytrityl)-N-acetyl-5-dimethylamino-2-deoxycytidine 
• 1363720-94-8 5'-(4,4'-dimethoxytrityl)-5-dimethylamino-2'-deoxyuridine 
• 168772-56-3 C₄₁H₄₁Br₂N₅O₁₂ 
• 194412-10-7 (1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester 
• 149725-99-5 2'-Deoxy-5'-O-(dimethoxytrityl)-5-trifluoroacetamidouridine 

Relevant academic research and scientific papers

Improved synthesis of 5-hydroxymethyl-2′-deoxycytidine phosphoramidite using a 2′-deoxyuridine to 2′-deoxycytidine conversion without temporary protecting groups

5-Hydroxymethylcytosine has recently been characterized as the 'sixth base' in human DNA. To enable research on this DNA modification, we report an improved method for the synthesis of 5-hydroxymethyl-2′-deoxycytidine (5-HOMedC) phosphoramidite for site-specific incorporation into oligonucleotides. To minimize manipulations we employed a temporary protecting group-free 2′-deoxyuridine to 2′-deoxycytidine conversion procedure that utilizes phase transfer catalysis. The desired 5-HOMedC phosphoramidite is obtained in six steps and 24% overall yield from 2′-deoxyuridine.

Synthesis of a carboxamide linked U(Br)*U(Br) dimer - Duplex and triplex stabilities of the corresponding oligodeoxynucleotides

A U(Br)*U(Br) dimer was synthesized by connecting the appropiate nucleoside monomers through a 5-atom carboxamide linkage. The dimer was incorporated in oligodeoxynucleotides and investigated for hybridization properties toward single and double stranded

Evaluation of oligonucleotides with novel modifications

Oligodeoxynucleotides modified with carboxamide linked dimeric nucleotides and an acyclic nucleoside were prepared and investigated for their hybridization properties toward DNA.