63664-41-5

Upstream product

• 674-82-8 4-methyleneoxetan-2-one 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 141-97-9 ethyl acetoacetate 
• 618-36-0 rac-methylbenzylamine 
• 1694-31-1 tert-butyl acetoacetate 
• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 

Downstream Products

• 88996-69-4 3-Methyl-1,4-dioxy-quinoxaline-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide 
• 139952-17-3 N-(1-phenylethyl)-3-hydroxybutyramide 
• 88996-83-2 3-Methyl-quinoxaline-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide 
• 1005459-66-4 (R,R)-N-(1-phenylethyl)-4-(2-chloro-4-fluorophenyl)-6-methyl-2-(2-thiazolyl)-1,4-dihydropyrimidin-5-carboxamide 
• 1203506-46-0 N₃-[(1R)-1-Phenylethyl]-6-chloro-2-methyl-4-phenyl-3-quinolinecarboxamide 
• 1005459-79-9 R,R-N-(1-phenylethyl)-4-(2-chloro-4-fluorophenyl)-2-(2,4,6-trifluorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide 
• 139952-19-5 (+)-N-(1(R)-phenylethyl)-3(S)-tert-butyldimethylsilyloxybutyramide 
• 139952-18-4 (+)-N-(1(R)-phenylethyl)-3(R)-tert-butyldimethylsilyloxybutyramide 
• 139952-17-3 (+)-N-(1(R)-phenylethyl)-3(S)-hydroxybutyramide 

Relevant academic research and scientific papers

An efficient synthesis of enantiopure (R)-heteroarylpyrimidine Analogs

An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs is described here, which involves introduction of a chiral group, formation and separation of diasteroisomers and final transformation of an amide to an ester. The absolute configuration of the enantiopure HAPs is confirmed by X-ray analysis of their intermediates.

Diversity-oriented synthesis of quinolines via Friedlaender annulation reaction under mild catalytic conditions

An efficient and practical method has been manifested for the diversity-oriented synthesis of quinolines via Friedlaender annulation reaction for the generation of a wide range of structurally interesting and pharmacologically significant compounds by using eerie ammonium, nitrate as a catalyst (10 mol %) at ambient temperature in 45 min, A variety of functional groups are introduced at various positions of the quinoline moiety, and further the diversity of the core skeleton was expanded at R1 and R 2 positions by the synthesis of various hybrids. Initial screening of the compounds for cytotoxicity against a series of cancer cell lines showed promising results.

Optically Pure Dihydropyrimidine Compounds and Their Uses for the Preparation of a Medicament for Treatment and Prevention of Viral Diseases

The present invention relates to an optically pure compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, a process for preparing the optically pure compound of formula (I), and use of the optically pure compound of formula (I)

OPTICAL PURE DIHYDROPYRIMIDINE COMPOUNDS, THEIR USES IN THE MANUFACTURE OF A MEDICAMNENT FOR THE TREATMENT OR THE PREVENTION OF VIROSIS DISEASES

The present invention relates to an optically pure compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, a process for preparing the optically pure compound of formula (I), and use of the optically pure compound of formula (I)

Lipase-catalyzed aminolysis and ammonolysis of β-ketoesters. Synthesis of optically active β-ketoamides.

Aminolysis and ammonolysis reactions of β-ketoesters catalyzed by Candida antarctica lipase are very efficient methods for the preparation of β- ketoamides. When racemic amines are used in these processes, the corresponding optically active β-ketoamides are obtained with moderate-high enantiomeric excesses.

Homochiral Amine Synthesis by Baker's Yeast Resolution of a β-Keto Amide: 1-Phenylethylamine

Preliminary investigation of the resolution potential of baker's yeast reduction of β-keto amides has been carried out with 1-phenylethylamine.Enantiomeric excess was determined by direct comparison of resolved enantiomers with derivatives prepared from c