63675-85-4Relevant academic research and scientific papers
Direct synthesis of 3-acylbenzothiophenes: Via the radical cyclization of 2-alkynylthioanisoles with α-oxocarboxylic acids
Liu, Wei,Hu, Yao-Qian,Hong, Xiao-Yi,Li, Guo-Xing,Huang, Xiao-Bo,Gao, Wen-Xia,Liu, Miao-Chang,Xia, Yuanzhi,Zhou, Yun-Bing,Wu, Hua-Yue
supporting information, p. 14148 - 14151 (2019/01/03)
A radical cascade cyclization of 2-alkynylthioanisoles with α-oxocarboxylic acids with AgNO3 has been described. This reaction provides a novel route to directly access 3-acylbenzothiophenes from simple chemical feedstocks. In particular, the utility of the approach was demonstrated by its application to the synthesis of a polymerization inhibitor and a raloxifene precursor.
Benzothiophene compounds, and uses and formulations thereof
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, (2008/06/13)
Benzothiophenes, and uses and formulations thereof, are provided by the present invention. The compounds are of the formula wherein R1and R2are independently -OH, -OCO(C1-C6alkyl), -O(CO)O(C1-C6alkyl), -OCO-Ar, where Ar is phenyl or substituted phenyl, or -O(CO)Ophenyl; and R3is a substituent in the 3 or 4 position of the phenyl ring selected from the group of -H, -Cl, -Br, -CH3, or -CH2CH3; or a pharmaceutically acceptable salt or solvate thereof, with the proviso that when R1and R2are both hydroxy, R3is not -H, -CH3, or -CH2CH3.
2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
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, (2008/06/13)
Derivatives of 2-phenyl-3-aroylbenzothiophenes and 2-phenyl-3-aroylbenzothiophene-1-oxides are useful as antifertility agents. Certain of these compounds also are useful in suppressing the growth of mammary tumors.
