63694-16-6

Basic information

• Product Name: Phosphonic acid, [(4-chlorophenyl)hydroxymethyl]-
• CAS NO: 63694-16-6
• Molecular Formula: C7H8ClO4P
• Molecular Weight: 222.565
• Mol File: 63694-16-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, [(4-chlorophenyl)hydroxymethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, [(4-chlorophenyl)hydroxymethyl]-(63694-16-6)
• EPA Substance Registry System: Phosphonic acid, [(4-chlorophenyl)hydroxymethyl]-(63694-16-6)

Safety Data

• Hazardous Substances Data: 63694-16-6(Hazardous Substances Data)

Upstream product

• 63694-11-1 C₁₆H₃₂ClO₄PSi₃ 
• 108054-54-2 diethyl (4-chlorophenyl)(hydroxy)methylphosphonate 
• 6329-48-2 dimethyl 1-hydroxy-1-(4-chlorophenyl)methylphosphonate 
• 104-88-1 4-chlorobenzaldehyde 

Relevant articles and documents

Hydrolysis and alcoholysis of phosphinates and phosphonates

Phosphinic and phosphonic acids useful intermediates and biologically active compounds may be prepared from their esters: phosphinates and phosphonates, respectively, by acid-catalyzed hydrolysis either on conventional heating or on MW irradiation. The transesterification of alkyl phosphinates took place only in the presence of suitable ionic liquids as the catalysts. In the cases of phenylphosphonates, depending on the nature of the ionic liquid, the formation of the ester was accompanied by the fission of the C–O bond.

Synthesis and anticancer cytotoxicity with structural context of an α-hydroxyphosphonate based compound library derived from substituted benzaldehydes

We synthesized substituted benzaldehyde derived α-hydroxyphosphonates (αOHP), α-hydroxyphosphonic acids (αOHPA) and α-phosphinoyloxyphosphonates (αOPP) and characterized their cytotoxicity against a panel of cancer cell lines. A library containing 56 analogues was screened against Mes-Sa parental and Mes-Sa/Dx5 multidrug resistant uterine sarcoma cell lines, using a fluorescence-based cytotoxicity assay. The cytotoxicity screening revealed that dibenzyl-αOHPs and dimethyl-α-diphenyl-OPPs were the most active clusters, which encouraged us to synthesize further dibenzyl-α-diphenyl-OPP derivatives that elicited pronounced cell killing. Further structure-activity relationships showed the relevance of hydrophobicity and the position of substituents on the main benzene ring as determinants of toxicity. The most active analogs proved to be equally, or even more toxic to the multidrug resistant (MDR) cell line Mes-Sa/Dx5, suggesting these compounds may overcome P-glycoprotein mediated multidrug resistance by evading the drug transporter.

Synthesis and herbicidal activity of novel dialkoxyphosphoryl aryl methyl 2-(4,6-dimethoxypyrimidin-2-yloxy) benzoate derivatives

A series of dialkoxyphosphoryl aryl methyl 2-(4,6-dimethoxy-pyrimidin-2- yloxy) benzoate derivatives was designed and synthesized. All new compounds were identified by elemental analysis, infrared (IR), 1H-NMR, and mass spectrometry (MS). Their herbicidal