63694-17-7

Upstream product

• 49640-96-2 diethyl (hydroxy(4-methoxyphenyl)methyl)phosphonate 
• 79296-58-5 [hydroxy-(4-methoxy-phenyl)-methyl]-phosphonic acid dimethyl ester 
• 123-11-5 4-methoxy-benzaldehyde 
• 63694-12-2 bis(trimethylsilyl) [(p-methoxyphenyl)(trimethylsiloxy)methyl]phosphonate 

Relevant academic research and scientific papers

Synthesis of new aryl-substituted methylphosphonic and methylenediphosphonic acids and their derivatives

Simple and versatile synthetic procedures towards new aryl-substituted hydroxymethylphosphonic and methylenediphosphonic acids via reactions of either aromatic aldehydes or their derivatives with phosphites were elaborated.

Synthesis of new functionalized aryl-substituted methylphosphonic and methylenediphosphonic acids and their derivatives

The convenient syntheses of new aryl-substituted hydroxymethylphosphonic and methylenediphosphonic acids from the aromatic aldehydes, their derivatives, and phosphorous acid esters in the presence of the effective catalysts (trimethylsilyl trifluoromethanesulfonate, zinc chloride, and cadmium iodide) were developed.

Synthesis and herbicidal activity of novel dialkoxyphosphoryl aryl methyl 2-(4,6-dimethoxypyrimidin-2-yloxy) benzoate derivatives

A series of dialkoxyphosphoryl aryl methyl 2-(4,6-dimethoxy-pyrimidin-2- yloxy) benzoate derivatives was designed and synthesized. All new compounds were identified by elemental analysis, infrared (IR), 1H-NMR, and mass spectrometry (MS). Their herbicidal

Synthesis of functionalized 1-trimethylsiloxy-substituted O-trimethylsilyl alkylphosphonites and their derivatives

Nucleophilic addition of trimethylsilyl esters of tricoordinate organophosphorus acids to various functionalized aldehydes with vinyl, aryl, and heterocyclic fragments is proposed as a convenient method for the synthesis of new 1-trimethylsiloxysubstituted alkylphosphonites and their derivatives at mild conditions. Also the new functionalized derivatives of these phosphonites, including amino groups as well as certain properties of these compounds as important precursors of new functionalized 1-hydroxyalkylorganophosphorus acids, are presented.

Novel hydroxyphosphonate inhibitors of CD-45 tyrosine phosphatase

CD-45 tyrosine phosphatase [E.C. 3.1.3.48] is an important player in the regulation of cell activation and proliferation in hematopoetic cells. As part of a program in immune response modulation, we prepared the first series of small organic molecule inhibitors of CD-45. The preparation and in vitro screening of these hydroxyphosphonates is described herein.

Silyl Phosphite Equivalents: 2,2,2-Trichloroethoxycarbonylphosphonates

2,2,2-Trichloroethoxycarbonylphosphonates were converted directly by treatment with Zn-Me3SiCl into silyl phosphites which in situ reacted with aldehydes to give α-hydroxyphosphonates in good yields.