63695-46-5

Upstream product

• 636-99-7 4-nitrophenylhydrazine hydrochloride 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 

Downstream Products

• 1384431-73-5 diethyl 1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-furo[2,3-c]pyrazole-4,5-dicarboxylate 
• 1384431-72-4 dimethyl 1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-furo[2,3-c]pyrazole-4,5-dicarboxylate 
• 1384431-60-0 4-diazo-1-(4-nitrophenyl)-3-trifluoromethylpyrazolin-5-one 

Relevant academic research and scientific papers

Novel hybrids of 3-n-butylphthalide and edaravone: Design, synthesis and evaluations as potential anti-ischemic stroke agents

Abstract Fourteen hybrids (10a-g, 11a-g) of 3-n-butylphthalide (NBP) and edaravone (Eda) analogues have been designed and synthesized as potential anti-ischemic stroke agents. In vitro biological studies showed that compounds 10d and 10g exhibited more potent anti-platelet aggregation than ticlopidine (Ticlid), aspirin (ASP) and NBP. Compound 10g more significantly prevented H2O2-mediated neuronal cell (PC12) death than NBP, Eda or NBP together with Eda. Meanwhile, 10g also possessed potent radical scavenging effects on hydroxyl radical (·OH) and superoxide anion radical (·O2-). Our findings may provide new insights into the development of these hybrids, like 10g, for the intervention of ischemic stroke.