636986-01-1

Basic information

• Product Name: Carbamic acid, (2-hydroxy-5-hexenyl)-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, (2-hydroxy-5-hexenyl)-, 1,1-dimethylethyl ester (9CI)
• CAS NO: 636986-01-1
• Molecular Formula: C11H21NO3
• Molecular Weight: 215.28934
• Product Categories: N-BOC
• Mol File: 636986-01-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 338.8±35.0 °C(Predicted)
• Appearance: /
• Density: 0.999±0.06 g/cm3(Predicted)
• PKA: 12.37±0.46(Predicted)
• CAS DataBase Reference: Carbamic acid, (2-hydroxy-5-hexenyl)-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (2-hydroxy-5-hexenyl)-, 1,1-dimethylethyl ester (9CI)(636986-01-1)
• EPA Substance Registry System: Carbamic acid, (2-hydroxy-5-hexenyl)-, 1,1-dimethylethyl ester (9CI)(636986-01-1)

Safety Data

• Hazardous Substances Data: 636986-01-1(Hazardous Substances Data)

Upstream product

• 10353-53-4 1,2-epoxy-5-hexene 
• 89711-08-0 N-(t-butoxycarbonyl)glycinal 
• 7051-34-5 cyclopropylcarbinyl bromide 
• 937375-53-6 1-aminohex-5-en-2-ol 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES

The present invention relates to amino-substituted imidazopyridazine compounds of general formula(I): in which A, R1, R3 and n are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

Dimerization and isomerization reactions of α-lithiated terminal aziridines

(Chemical Equation Presented) The scope of dimerization and isomerization reactions of α-lithiated terminal aziridines is detailed. Regio-and stereoselective deprotonation of simple terminal aziridines with lithium 2,2,6,6-tetramethylpiperidide (LTMP) or lithium dicyclohexylamide (LiNCy 2) generates trans-α-lithiated terminal aziridines. These latter species can then undergo dimerization or isomerization reactions depending on the nature of the N-protecting group. α-Lithiated terminal aziridines bearing N-alkoxycarbonyl (Boc) protection undergo N- to C-[1,2] migration to give N-H trans-aziridinylesters. In contrast, aziridines bearing N-organosulfonyl [tert-butylsulfonyl (Bus)] protection undergo rapid dimerization to give 2-ene-1,4-diamines or, if a pendant alkene is present, diastereoselective cyclopropanation to give 2-aminobicyclo[3.1.0]hexanes. All of these reactions were used as key steps in the preparation of synthetically and biologically important targets.