937375-53-6

Basic information

• Product Name: 1-Amino-hex-5-en-2-ol
• Synonyms: 1-Amino-hex-5-en-2-ol
• CAS NO: 937375-53-6
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.17352
• Product Categories: pharmacetical
• Mol File: 937375-53-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Amino-hex-5-en-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Amino-hex-5-en-2-ol(937375-53-6)
• EPA Substance Registry System: 1-Amino-hex-5-en-2-ol(937375-53-6)

Safety Data

• Hazardous Substances Data: 937375-53-6(Hazardous Substances Data)

Usage

Type of compound

Amino alcohol

Functional groups

Amine and alcohol

Structure

A derivative of hex-5-en-2-ol with an amino group attached to the first carbon of the alkene chain

Synthesis

Can be synthesized through various chemical reactions

Applications

Used in organic synthesis as a building block for the preparation of more complex molecules

Industry relevance

Potential applications in the pharmaceutical industry and in the development of new materials

Chemical properties

Valuable compound in chemical research and development due to its properties and reactivity

Upstream product

• 2100-17-6 4-pentenal 
• 10353-53-4 1,2-epoxy-5-hexene 
• 925210-14-6 (+/-)-1-nitro-hex-5-en-2-ol 

Downstream Products

• 636986-01-1 tert-butyl 2-hydroxyhex-5-enylcarbamate 
• 925209-89-8 (+/-)-N-(2-hydroxy-hex-5-enyl)-4-methyl-benzenesulfonamide 

Relevant articles and documents

NRF2 REGULATORS

The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.

Dimerization and isomerization reactions of α-lithiated terminal aziridines

(Chemical Equation Presented) The scope of dimerization and isomerization reactions of α-lithiated terminal aziridines is detailed. Regio-and stereoselective deprotonation of simple terminal aziridines with lithium 2,2,6,6-tetramethylpiperidide (LTMP) or lithium dicyclohexylamide (LiNCy 2) generates trans-α-lithiated terminal aziridines. These latter species can then undergo dimerization or isomerization reactions depending on the nature of the N-protecting group. α-Lithiated terminal aziridines bearing N-alkoxycarbonyl (Boc) protection undergo N- to C-[1,2] migration to give N-H trans-aziridinylesters. In contrast, aziridines bearing N-organosulfonyl [tert-butylsulfonyl (Bus)] protection undergo rapid dimerization to give 2-ene-1,4-diamines or, if a pendant alkene is present, diastereoselective cyclopropanation to give 2-aminobicyclo[3.1.0]hexanes. All of these reactions were used as key steps in the preparation of synthetically and biologically important targets.