637-32-1

Basic information

• Product Name: PROGUANIL HYDROCHLORIDE
• Synonyms: 1-(p-chlorophenyl)-5-isopropylbiguanidehydrochloride;1-(p-chlorophenyl)-5-isopropyl-biguanidmonohydrochloride;3359rp;chlorguanidehydrochloride;chloroguanidehydrochloride;chloroguanidinehydrochloride;diguanyl;drinupalhydrochloride
• CAS NO: 637-32-1
• Molecular Formula: C₁₁H₁₆ClN₅*ClH
• Molecular Weight: 290.19
• EINECS: 211-283-7
• Product Categories: Aromatics;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;PALUDRINE
• Mol File: 637-32-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 249-2510C
• Boiling Point: 402.7oC at 760 mmHg
• Flash Point: 197.4oC
• Appearance: /
• Vapor Pressure: 1.07E-06mmHg at 25°C
• Storage Temp.: -20°C Freezer
• Solubility: acetonitrile: water: ~1mg/mL (60/40)
• CAS DataBase Reference: PROGUANIL HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PROGUANIL HYDROCHLORIDE(637-32-1)
• EPA Substance Registry System: PROGUANIL HYDROCHLORIDE(637-32-1)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: 3249
• WGK Germany: 3
• RTECS: DU1750000
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 637-32-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 637-32-1 differently. You can refer to the following data:
1. Chlorguanide Hydrochloride can be intended for use as an internal standard for the quantification of Proguanil by GC- or LC-mass spectrometry.
2. Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug.
3. Antimalarial

General Description

Proguanil hydrochloride is a biguanide compound, widely used as an antimalarial drug. It exhibits sporontocidal activity, thereby rendering the gametocytes non-infective to the mosquito vector.Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biochem/physiol Actions

Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.

InChI:InChI=1/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H

Downstream Products

• 12572-07-5 {Os(ClC₆H₄C₂H₅N₅C₃H₇)2Cl₂}⁽¹⁺⁾*Cl^(1-)={Os(ClC₆H₄C₂H₅N₅C₃H₇)2Cl₂}Cl 
• 12572-06-4 {Os(ClC₆H₄C₂H₅N₅C₃H₇)2Br₂}⁽¹⁺⁾*Br^(1-)={Os(ClC₆H₄C₂H₅N₅C₃H₇)2Br₂}Br 

Relevant articles and documents

BIGUANIDE COMPOUND AND USE THEREOF

The present invention relates to a guanidine compound and a use thereof, and more specifically, to a guanidine derivative showing excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence; a preparation method thereof; and a pharmaceutical composition containing the same as an active ingredient. Compared to existing drugs, the guanidine derivative according to the present invention shows excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence even with small doses, and may thus be effectively used in preventing or treating various cancers such as uterine cancer, breast cancer, stomach cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, liver cancer, etc., inhibiting cancer cell proliferation and cancer metastasis.