63717-27-1

Basic information

• Product Name: Amifostine hydrate
• Synonyms: AMIFOSTINE HYDRATE;2-((3-aminopropyl)amino)-ethanethiodihydrogenphosphate(ester)hydrate;phosphorothioicacid,s-(2-((3-aminopropyl)amino)ethyl)ester,hydrate;phosphorothioicacid,s-esterwith2-((3-aminopropyl)amino)ethanethiol,hydra;Amifostinum [INN-Latin];Phosphorothioic acid 2-((3-aminopropyl)amino)ethanethiol S-ester hydrate;Amifostina;Amifostina [inn-spanish]
• CAS NO: 63717-27-1
• Molecular Formula: C5H17N2O4PS
• Molecular Weight: 232.24
• Mol File: 63717-27-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 160-161° (dec)
• Boiling Point: 441.7°C at 760 mmHg
• Flash Point: 220.9°C
• Appearance: /
• Vapor Pressure: 4.9E-09mmHg at 25°C
• CAS DataBase Reference: Amifostine hydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Amifostine hydrate(63717-27-1)
• EPA Substance Registry System: Amifostine hydrate(63717-27-1)

Safety Data

• Hazardous Substances Data: 63717-27-1(Hazardous Substances Data)

Usage

Safety Profile

Poison by unspecified route.Moderately toxic by intraperitoneal route. When heated todecomposition it emits very toxic fumes of NOx, POx, andSOx. See also ESTERS

InChI:InChI=1/C5H15N2O3PS.H2O/c6-2-1-3-7-4-5-12-11(8,9)10;/h7H,1-6H2,(H2,8,9,10);1H2

Upstream product

• 23545-42-8 dibromohydrate du N-(bromoethyl-2)diamino-1,3 propane 

Downstream Products

• 112901-68-5 S-(2-(3-aminopropylamino)ethyl)phosphorothioic acid dihydrate 
• 112901-68-5 amifostine trihydrate 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF (ω -AMINOALKYLAMINO)ALKYL HALIDES AND CONVERSION TO AMIFOSTINE

The present invention relates to processes for the preparation of (ω- aminoalkylainino)alkyl halides, their conversion to S-ω-(ω-aminoalkylamino)alkyl phosphothioates, and purification of the crystalline products of the reaction. The preparation process for the (ω-aminoalkylamino)alkyl halides comprises contacting an appropriate alcohol with a brominating agent in the presence of a sulfone solvent under temperature and pressure conditions suitable to effect salt formation without subsequent premature precipitation. The process is especially useful for converting (ω-aminoalkylamino)ethyl alcohol to amifostine.