6372-57-2

Usage

InChI:InChI=1/C22H19NO/c24-22(19-14-8-3-9-15-19)21-20(18-12-6-2-7-13-18)23(21)16-17-10-4-1-5-11-17/h1-15,20-21H,16H2

Upstream product

• 100-46-9 benzylamine 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 32147-20-9 (Z)-2-bromo-1,3-diphenylprop-2-en-1-one 
• 294886-82-1 2-benzyl-3,5-diphenyl-2,3-dihydro-isoxazole 
• 294886-74-1 N-benzyl-N-(1,3-diphenylprop-2-yn-1-yl)hydroxylamine 
• 3376-26-9 N-Benzylidenebenzylamine N-oxide 
• 536-74-3 phenylacetylene 
• 3376-26-9 N-Benzylidenbenzylamin-N-oxid 
• 611-91-6 2,3-dibromo-1,3-diphenylpropane-1-one 
• 611-91-6 trans-2,3-dibromo-1,3-diphenylpropan-1-one 

Downstream Products

• 6628-56-4 (+/-)-benzyl-(1,3,5t-triphenyl-4,5-dihydro-1H-pyrazol-4r-yl)-amine 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 2183-27-9 1,3,5-triphenyl-1H-pyrazole 
• 279690-85-6 Dimethyl N-benzyl-N-(2-oxo-2-phenylethyl)amino-1-phenylmethylphosphonate 
• 1258314-43-0 C₃₃H₂₉NO₂ 
• 1353722-06-1 benzyl 1-benzyl-2-methyl-4-phenyl-1H-pyrrole-3-carboxylate 
• 1353722-09-4 benzyl 1-benzyl-5-(1'-hydroxy-1'-phenylmethyl)-2-methyl-4-phenyl-1H-pyrrole-3-carboxylate 
• 1353722-08-3 benzyl 1-benzyl-2-ethyl-4-phenyl-1H-pyrrole-3-carboxylate 
• 1353722-07-2 benzyl 1,2-dibenzyl-4-phenyl-1H-pyrrole-3-carboxylate 

Relevant academic research and scientific papers

I2/TBHP mediated diastereoselective synthesis of spiroaziridines

Eventhough spiroheterocycles are considered as emerging drug candidates, synthesis of spiroaziridines has not been well explored so far. Herein, we disclose an efficient I2/TBHP mediated diastereoselective synthesis of N-alkyl spiroaziridines from primary amines and easily accessible α,β-unsaturated ketones. The reaction is also compatible for the synthesis of 2-aroylaziridines.

Oxygenation of Simple Olefins through Selective Allylic C?C Bond Cleavage: A Direct Approach to Cinnamyl Aldehydes

A novel metal-free allylic C?C σ-bond cleavage of simple olefins to give valuable cinnamyl aldehydes is reported. 1,2-Aryl or alkyl migration through allylic C?C bond cleavage occurs in this transformation, which is assisted by an alkyl azide reagent. This method enables O-atom incorporation into simple unfunctionalized olefins to construct cinnamyl aldehydes. The reaction features simple hydrocarbon substrates, metal-free conditions, and high regio- and stereoselectivity.

A Lewis acid/metal amide hybrid as an efficient catalyst for carbon-carbon bond formation

While Lewis acids and metal amides are among the most frequently used metal species, they are believed to be incompatible when combined. Here we describe a Lewis acid/metal amide hybrid, which contains electron-withdrawing groups and basic and bulky nitro

Selective transformation of N-(propargylic)hydroxylamines into 4-isoxazolines and acylaziridines promoted by metal salts

Cyclization of N-(propargylic)hydroxylamines catalyzed by AgBF4 afforded the corresponding 4-isoxazolines in good yields. Copper salts were found to promote the further transformation to acylaziridines. The combined use of AgBF4 and CuCl realiz

Dicobalt Octacarbonyl Promoted Rearrangement of 4-Isoxazolines to Acylaziridines: Dramatic Rate Acceleration with Very High Substrate Tolerance

(Matrix Presented) Dicobalt octacarbonyl [Co2(CO)8] in acetonitrile at 75 °C triggers the cleavage of the N-O bond of 4-isoxazolines (1) to bring about the valence rearrangement to 2-acylaziridines (2). The isoxazolines were stable a

Unusual reactivity of cis-2-benzoyl-1-benzyl-3-phenylaziridine with p-nucleophiles - Ring opening vs. the Abramov reaction

Thermal (80 °C) addition of dimethyl phosphite to cis-2-benzoyl-1-benzyl-3-phenylaziridine occurred exclusively at C(3) with concomitant cleavage of the C(2)-C(3) bond. The carbonyl group in the aminoketone produced under these conditions was reduced with hydrogen over Pearlman's catalyst with low (20%) diastereoselectivity, while good (80%) de was observed in the NaBH4 reduction as a result of the 1,4-asymmetric induction. The products of the Abramov reaction of the title compound were obtained (de 92%) when CsF was used as catalyst.

A Rapid Synthesis of Aziridine Derivatives over Bentonite in 'Dry Media'

Functionalized aziridines are synthesized from dibromo compounds and primary aliphatic amines in the absence of solvent over bentonite as a solid support; in some examples microwave activation is compared to normal heating.