6372-65-2

Usage

Uses

Used in Pharmaceutical Industry:
(5Z)-2-amino-5-5-chloro-2-[2-(4-methylphenoxy)ethoxy]benzylidene-1,3-thiazol-4(5H)-one is used as a potential pharmaceutical agent for its diverse biological activities. (5Z)-2-amino-5-5-chloro-2-[2-(4-methylphenoxy)ethoxy]benzylidene-1,3-thiazol-4(5H)-one's antimicrobial, antiviral, and anti-inflammatory properties make it a candidate for the development of new drugs to treat various diseases and conditions.
Used in Research and Development:
In the field of scientific research, (5Z)-2-amino-5-5-chloro-2-[2-(4-methylphenoxy)ethoxy]benzylidene-1,3-thiazol-4(5H)-one serves as a subject for further investigation into its biological activity. Understanding the compound's interactions with biological systems can lead to the discovery of new therapeutic targets and the optimization of its pharmacological properties.

Upstream product

• 77154-92-8 9,10-dihydro-9,10-ethanoanthracen-11-one oxime 
• 58286-94-5 (9,10-dihydro-9,10-ethano-anthracen-11-yl)-carbamic acid ethyl ester 
• 77154-92-8 hydroxyimino-11 ethano-9,10-dihydro-9,10 anthracene 
• 6372-63-0 9,10-dihydro-9,10-ethanoanthracen-11-one 

Downstream Products

• 593-67-9 vinylamine 
• 120-12-7 anthracene 

Relevant academic research and scientific papers

Geometry-affinity relationships of the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene

With the exception of its two aromatic rings and basic nitrogen atom, 9-(aminomethyl)-9,10-dihydroanthracene (AMDA; 1) is remarkably devoid of the pharmacophore features usually associated with high-affinity receptor ligands such as the heteroatom hydrogen bonding features of the endogenous ligand serotonin. AMDA does contain a phenylethylamine skeleton within a tricyclic ring system, and the presence of the second aromatic group is necessary for optimal receptor affinity. The structural requirements for the binding of AMDA at 5-HT2A receptors were investigated with respect to the geometric relationship between the two aromatic rings. It appears that the geometry of the AMDA parent is in the optimal range for fold angle between aromatic moieties. Evaluation of conformationally constrained derivatives of AMDA suggests that a chain extended trans, gauche form is most likely responsible for high affinity.

REACTIONS RETRODIENIQUES-IX. SYNTHESE PAR THERMOLYSE ECLAIR ET ETUDE D'ENAMINES PRIMAIRES INSTABLES

Etheneamine 1 and its methyl derivatives 2-7 have been synthesized from the adducts 8-14 by a retro-Diels-Alder reaction under flash thermolytic conditions.The primary enamines 1-4 have been identified (IR, (1)H and (13)C NMR in a pure state at -80 deg C; at the same temperature, the enamines 5-7, less stable, are already accompanied by their tautomeric imines 33 or 34.When warmed up to room temperature, the enamines 1-7 lead, following to their substitution, either to nitrogen heterocycles (30, 42) or to acyclic azadienes (35-37, 39, 40).