63721-14-2

Basic information

• Product Name: NH-(PEG3-OH)2
• Synonyms: NH-(PEG3-OH)2;NH-bis(PEG3-OH)
• CAS NO: 63721-14-2
• Molecular Formula: C16H35NO8
• Molecular Weight: 369.451
• Mol File: 63721-14-2.mol

Chemical Properties

• Boiling Point: 482.3±40.0 °C(Predicted)
• Appearance: /
• Density: 1.104±0.06 g/cm3(Predicted)
• PKA: 14.06±0.10(Predicted)
• CAS DataBase Reference: NH-(PEG3-OH)2(CAS DataBase Reference)
• NIST Chemistry Reference: NH-(PEG3-OH)2(63721-14-2)
• EPA Substance Registry System: NH-(PEG3-OH)2(63721-14-2)

Safety Data

• Hazardous Substances Data: 63721-14-2(Hazardous Substances Data)

Usage

Uses

Used in Bioconjugation:
NH-(PEG3-OH)2 is used as a bioconjugation agent for the formation of stable amide bonds with activated NHS esters. This application is particularly valuable in the development of biocompatible materials and the creation of conjugates for various biological and medical purposes.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, NH-(PEG3-OH)2 serves as a key component in drug delivery systems. Its ability to form stable bonds with a variety of molecules allows for the development of targeted drug delivery platforms, potentially improving the efficacy and reducing the side effects of certain medications.
Used in Chemical Synthesis:
NH-(PEG3-OH)2 is utilized as an intermediate in the synthesis of more complex PEGylated molecules. Its central amino group and terminal hydroxyl groups make it a versatile building block for creating a wide array of PEG-based polymers and copolymers with tailored properties for specific applications.
Used in Cosmetics and Personal Care:
In the cosmetics and personal care industry, NH-(PEG3-OH)2 is used as an ingredient to improve the solubility, stability, and biocompatibility of various formulations. Its presence can enhance the performance of creams, lotions, and other topical products, providing benefits such as increased hydration and improved skin feel.
Used in Diagnostics:
NH-(PEG3-OH)2 plays a role in the development of diagnostic tools, where it can be used to create contrast agents or markers for imaging techniques. Its ability to form stable bonds with imaging agents allows for the creation of more effective and safer diagnostic products.
Overall, NH-(PEG3-OH)2 is a multifunctional molecule with a broad range of applications across various fields, thanks to its unique structure and reactivity. Its uses in bioconjugation, pharmaceuticals, chemical synthesis, cosmetics, and diagnostics highlight its versatility and potential for further development and innovation.

Upstream product

• 112-60-7 Tetraethylene glycol 
• 77544-60-6 p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester 
• 86770-67-4 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol 

Downstream Products

• 1258939-38-6 tert-butyl bis(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)carbamate 

Relevant articles and documents

Synthesis of branched monodisperse oligoethylene glycols and 19f mri-traceable biomaterials through reductive dimerization of azides

Multifunctionalized and branched M-OEGs represent valuable PEGylation agents, linkers, and scaffolds in biomedicine. However, the tedious synthesis limited their availability and application. We herein present an azide reductive dimerization method for the convenient synthesis of aza-M-OEGs and derivatives, which provides easy access to a variety of multifunctionalized and branched M-OEGs in one step. With this method, hexa-arm M-OEGs with 54 symmetrical fluorines were synthesized in two steps as a water-soluble, self-assemble, 19F MRI sensitive, and biocompatible dendritic biomaterial.

Expedient synthesis of trifunctional oligoethyleneglycol-amine linkers and their use in the preparation of PEG-based branched platforms

We designed a convergent synthesis pathway that provides access to trifunctional oligoethyleneglycol-amine (OEG-amine) linkers. By applying the reductive coupling of a primary azide to bifunctional OEG-azide precursors, the corresponding symmetrical dialkylamine bearing two homo-functional end chain groups and a central nitrogen was obtained. These building blocks bear minimal structural perturbation compared to the native OEG backbone which makes them attractive for biomedical applications. The NMR investigations of the mechanism process reveal the formation of nitrile and imine intermediates which can react with the reduced free amine form. Additionally, these trifunctional OEG-amine linkers were employed in a coupling reaction to afford branched multifunctional PEG dendrons which are molecularly defined. These discrete PEG-based dendrons (n = 16, 18 and 36) could be useful for numerous applications where multivalency is required.