637352-38-6

Usage

Uses

Used in Organic Synthesis:
2-bromo-6-(4-(trifluoromethyl)phenyl)pyridine is used as a building block in organic synthesis for its ability to contribute to the formation of complex molecular structures. Its strong electron-withdrawing and steric effects facilitate the synthesis of various organic compounds.
Used in Pharmaceutical Research:
In pharmaceutical research, 2-bromo-6-(4-(trifluoromethyl)phenyl)pyridine serves as a key intermediate, aiding in the development of new drugs. Its unique properties allow for the creation of novel pharmaceutical compounds with potential therapeutic applications.
Used as a Precursor in Pharmaceutical and Agrochemical Synthesis:
2-bromo-6-(4-(trifluoromethyl)phenyl)pyridine is utilized as a precursor in the synthesis of a variety of pharmaceutical and agrochemical compounds. Its reactivity and structural features make it instrumental in the production of new molecules with desired biological activities.
Used in the Development of New Chemical Entities:
2-broMo-6-(4-(trifluoroMethyl)phenyl)pyridine is employed in the development of new chemical entities due to its versatility and the potential for creating molecules with unique properties. Its electron-withdrawing and steric effects are particularly useful in designing molecules with specific reactivity profiles.

Upstream product

• 626-05-1 2,6-Dibromopyridine 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 718628-25-2 (4-(trifluoromethyl)phenyl)zinc(II) iodide 

Downstream Products

• 637353-31-2 N-2-propen-1-yl-6-[4-(trifluoromethyl)phenyl]-2-pyridinamine 

Relevant academic research and scientific papers

Group 4 Post-Metallocenes Supported by [OCH2 N,C(σ-aryl)] Auxiliaries Bearing a Seven-Membered Metallacycle: Synthesis, Characterization, and Catalysts for Olefin Polymerization

A series of pyridine-2-phenolate-6-(σ-aryl) [OCH2 N,C] group 4 bis(benzyl) precatalysts, featuring a flexible O,N-donor chelate, have been prepared and characterized by multinuclear NMR spectroscopy. These complexes adopt C1/su

Selective Suzuki-Miyaura monocouplings with symmetrical dibromoarenes and aryl ditriflates for the one-pot synthesis of unsymmetrical triaryls

The various parameters that would permit selective Suzuki-Miyaura monocouplings of symmetrical dihaloarenes were studied. High selectivity and efficiency can be obtained for a broad range of substrates by using operationally simple conditions and widely available reagents. The 38 different examples described provide a valuable toolbox for the rapid access to unsymmetrical triaryls, as illustrated by the preparation of diarylpyridine 8, terphenyl 9, and diarylpyrrole 10. By studying several key parameters, the factors that allow selective Suzuki-Miyaura monocoupling of symmetrical dihaloarenes have been outlined. This study serves as the basis for the efficient synthesis of unsymmetrical triaryls from symmetrical dibromoarenes and aryl ditriflates by a one-pot desymmetrizing double Suzuki-Miyaura coupling. Copyright

CHEMICAL COMPOUNDS

A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, .Wherein:R1 and R2 are independently hydrogen or C1-3 alkyl;X represents a bond, CH2 or O;R3 and R4 are independently hydrogen, C1-6 alkyl, OCH3, CF3, allyl or halogen;X1 is CH2, SO2, or CO;R5 is -C1-6 alkyl (optionally substituted by C1-6alkoxy or C1-6alkylthio), -C2-6 alkenyl, -C0-6 alkyl phenyl (wherein the phenyl is optionally substituted by one or more CF3, halogen, C1-3 alkyl, C1-3 alkoxy), -COC1-6 alkyl, SO2C1-6 alkyl ;R6 is phenyl or a 6 membered heteroaryl group containing 1,2 or 3 N atoms wherein the phenyl or heteroaryl group is optionally substituted with 1, 2 or 3 moieties selected from the group consisting of C1-6 alkyl, halogen, -OC1-6 alkyl, -SO2C1-3 alkyl, phenyl (optionally substituted by one or more groups selected from halogen, CF3, C1-3 alkyl, OC1-3 alkyl, acetyl, CN).