637352-85-3

Basic information

• Product Name: 2-CHLORO-6-(4-METHYLPHENYL)PYRAZINE
• Synonyms: 2-CHLORO-6-(4-METHYLPHENYL)PYRAZINE;2-chloro-6-p-tolylpyrazine
• CAS NO: 637352-85-3
• Molecular Formula: C₁₁H₉ClN₂
• Molecular Weight: 204.66
• Mol File: 637352-85-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 72.5-73.7 °C
• Boiling Point: 313.0±37.0 °C(Predicted)
• Appearance: /
• Density: 1.208±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.31±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-6-(4-METHYLPHENYL)PYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-(4-METHYLPHENYL)PYRAZINE(637352-85-3)
• EPA Substance Registry System: 2-CHLORO-6-(4-METHYLPHENYL)PYRAZINE(637352-85-3)

Safety Data

• Hazardous Substances Data: 637352-85-3(Hazardous Substances Data)

Usage

General Description

2-CHLORO-6-(4-METHYLPHENYL)PYRAZINE is a chemical compound with the molecular formula C11H9ClN2. It is a heterocyclic organic compound and belongs to the pyrazine class of chemicals. This chemical is a pale yellow to brown liquid with a molecular weight of 208.65 g/mol. It is primarily used as an intermediate for the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block in organic synthesis and as a reagent in chemical research. 2-CHLORO-6-(4-METHYLPHENYL)PYRAZINE is known for its potential as an anticancer agent and is currently being studied for its pharmaceutical applications.

Upstream product

• 922524-99-0 2-p-tolylpyrazine 1-oxide 
• 4774-14-5 2,6-dichloropyrazine 
• 5720-05-8 4-methylphenylboronic acid 

Downstream Products

• 637352-89-7 ethyl [4-({butyl[6-(4-methylphenyl)pyrazin-2-yl]amino}methyl)-2-methylphenoxy]acetate 
• 637352-87-5 2-bromo-6-(4-methylphenyl)pyrazine 

Relevant articles and documents

Use of N-oxide compounds in coupling reactions

Metal-catalyzed coupling process comprising reacting a compound of general formula 1 with a compound A-X, to obtain a compound of general formula 2, which may further be converted to a compound of general formula 3

CHEMICAL COMPOUNDS

A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, .Wherein:R1 and R2 are independently hydrogen or C1-3 alkyl;X represents a bond, CH2 or O;R3 and R4 are independently hydrogen, C1-6 alkyl, OCH3, CF3, allyl or halogen;X1 is CH2, SO2, or CO;R5 is -C1-6 alkyl (optionally substituted by C1-6alkoxy or C1-6alkylthio), -C2-6 alkenyl, -C0-6 alkyl phenyl (wherein the phenyl is optionally substituted by one or more CF3, halogen, C1-3 alkyl, C1-3 alkoxy), -COC1-6 alkyl, SO2C1-6 alkyl ;R6 is phenyl or a 6 membered heteroaryl group containing 1,2 or 3 N atoms wherein the phenyl or heteroaryl group is optionally substituted with 1, 2 or 3 moieties selected from the group consisting of C1-6 alkyl, halogen, -OC1-6 alkyl, -SO2C1-3 alkyl, phenyl (optionally substituted by one or more groups selected from halogen, CF3, C1-3 alkyl, OC1-3 alkyl, acetyl, CN).