637352-85-3

Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-6-(4-METHYLPHENYL)PYRAZINE is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
2-CHLORO-6-(4-METHYLPHENYL)PYRAZINE also serves as an intermediate in the production of agrochemicals, playing a role in the creation of pesticides and other agricultural products to protect crops and enhance yields.
Used in Organic Synthesis:
2-CHLORO-6-(4-METHYLPHENYL)PYRAZINE is utilized as a building block in organic synthesis, enabling the construction of complex organic molecules for a wide range of applications.
Used in Chemical Research:
As a reagent, 2-CHLORO-6-(4-METHYLPHENYL)PYRAZINE is employed in chemical research to facilitate experiments and investigations, furthering scientific understanding and innovation in the field.
Used in Anticancer Applications:
2-CHLORO-6-(4-METHYLPHENYL)PYRAZINE is being studied for its potential as an anticancer agent, with ongoing research aimed at understanding its mechanisms of action and efficacy in combating cancer cells.

Upstream product

• 922524-99-0 2-p-tolylpyrazine 1-oxide 
• 4774-14-5 2,6-dichloropyrazine 
• 5720-05-8 4-methylphenylboronic acid 

Downstream Products

• 637352-89-7 ethyl [4-({butyl[6-(4-methylphenyl)pyrazin-2-yl]amino}methyl)-2-methylphenoxy]acetate 
• 637352-87-5 2-bromo-6-(4-methylphenyl)pyrazine 

Relevant academic research and scientific papers

Use of N-oxide compounds in coupling reactions

Metal-catalyzed coupling process comprising reacting a compound of general formula 1 with a compound A-X, to obtain a compound of general formula 2, which may further be converted to a compound of general formula 3

Palladium-catalyzed cross-coupling reactions of diazine N-oxides with aryl chlorides, bromides, and iodides

New aspects of N-oxides: Pyrazine, pyridazine, and pyrimidine N-oxides are regioselectively arylated with aryl iodides, bromides, and chlorides in the presence of a palladium catalyst (see scheme). The resulting products can be deoxygenated in high yield

CHEMICAL COMPOUNDS

A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, .Wherein:R1 and R2 are independently hydrogen or C1-3 alkyl;X represents a bond, CH2 or O;R3 and R4 are independently hydrogen, C1-6 alkyl, OCH3, CF3, allyl or halogen;X1 is CH2, SO2, or CO;R5 is -C1-6 alkyl (optionally substituted by C1-6alkoxy or C1-6alkylthio), -C2-6 alkenyl, -C0-6 alkyl phenyl (wherein the phenyl is optionally substituted by one or more CF3, halogen, C1-3 alkyl, C1-3 alkoxy), -COC1-6 alkyl, SO2C1-6 alkyl ;R6 is phenyl or a 6 membered heteroaryl group containing 1,2 or 3 N atoms wherein the phenyl or heteroaryl group is optionally substituted with 1, 2 or 3 moieties selected from the group consisting of C1-6 alkyl, halogen, -OC1-6 alkyl, -SO2C1-3 alkyl, phenyl (optionally substituted by one or more groups selected from halogen, CF3, C1-3 alkyl, OC1-3 alkyl, acetyl, CN).