63741-56-0Relevant academic research and scientific papers
Short, stereoselective syntheses of α-fluoroalkenoate derivatives, α- fluoroenones and α-fluoroenals from HFC-134a
Kanai,Percy
, p. 2453 - 2455 (2007/10/03)
Readily-available 1,1,1,2-tetrafluoroethane (Klea HFC-134a) can be converted, via a two-pot sequence into a range of Z-α-fluoroalkenoyl derivatives following addition reactions to aldehydes. Reaction adducts can be processed into enals and enones upon hydride reduction or Grignard reagent addition in high yield. (C) 2000 Elsevier Science Ltd.
A general and efficient synthesis of β-ketophosphonates
Coutrot, Philippe,Grison, Claude,Lachgar, Mohamed,Ghribi, Abdelaziz
, p. 925 - 942 (2007/10/02)
The acylation of organocuprates or organolithiated reagents with 2-dialkylphosphonoalkanoyl chlorides or dialkylphosphonofluoroacetyl chlorides represents a general and efficient route to β-ketophosphonates.A Horner reaction between the lithiated anions derived from α-fluoro-β-ketophosphonates and aldehydes leads to 2-fluoro-2-enones whereas the lithiated anions derived from γ-acetylenic-β-ketophosphonates afford enynones. β-ketophosphonate / 2-dialkylphosphonoalkanoyl chloride / dialkylphosphonofluoroacetyl chloride / 2-fluoro-2-enone / enynone
SYNTHESE GENERALE DE β-CETOPHOSPHONATES α-FLUORES PRECURSEURS D'ENONES α-FLUOREES, APPLICATION EN SERIE PYRETHRENIQUE.
Coutrot, Ph.,Grison, C.
, p. 2655 - 2658 (2007/10/02)
Dialkylphosphonoflouracetylchlorides are used to introduce directly the 2-oxophosphonate 1-fluorinated synthons on organometallic reagents.A Horner reaction of the 3 derivated anions with aldehydes gave various 2-fluoro-2-enones.Application to the cis, trans caronaldehyde ethyl ester led to the 2-fluoroethenyl pyrethroid derivatives.
