63755-08-8

Upstream product

• 19952-47-7 4-chlorobenzo[d]thiazol-2-amine 
• 3048-45-1 4-chloro-1,3-benzothiazole 

Downstream Products

• 40925-72-2 2-amino-3-chlorobenzenethiol 
• 1263798-26-0 C₉H₉ClN₂S 
• 1263798-51-1 C₁₁H₁₄ClNO₂S 
• 189883-70-3 (+/-)-α-{[3-chloro-2-(1H-pyrrol-1-yl)phenyl]thio}phenylacetic acid 
• 177578-93-7 10-Chloro-5-phenyl-6-thia-10b-aza-benzo[e]azulen-4-one 
• 875895-77-5 2-(2-amino-3-chloro-phenylsulfanylmethyl)-benzoic acid methyl ester 
• 875895-89-9 [2-(2-amino-3-chloro-phenylsulfanylmethyl)-phenyl]-methanol 
• 189883-68-9 bis(3-chloro-2-N-pyrrolylphenyl)disulfide 

Relevant academic research and scientific papers

New 3,1,2,4-benzothiaselenadiazines, related π-heterocycles including Herz cations, radicals and molecular complexes, and Bunte salts

New chalcogen-nitrogen π-heterocycles covering 3,1,2,4-benzothiaselenadiazines, 1,3,2,4-benzodithiadiazines and 1,2,4,3,5-benzotrithiadiazepines were synthesized via the electrophilic cyclization of compounds Ar-NSN-SiMe3 under the action of SeCl2, SeCl4/FeCp2, SCl2 and S2Cl2. Heterocycles obtained were thermolyzed into persistent 2,1,3-benzothiaselenazolyls and 1,2,3-benzodithiazolyls (Herz radicals), which were characterized using EPR spectroscopy and DFT calculations. Reaction of the archetypal 3,1,2,4-benzothiaselenadiazine with SCl2 afforded 2,1,3-benzothiaselenazolium chloride (Herz salt), whereas that of sterically hindered 1,3,2,4-benzodithiadiazine resulted in a complex of the corresponding Herz salt with unexpected carbocycle-chlorinated and non-chlorinated 3,3-dioxides of the starting material, which is a rare example of a molecular complex involving a Herz cation. Formation of the dioxides can be explained through intermediate participation of the benzodithiadiazine radical cation. Hydrolysis of 3,1,2,4-benzothiaselenadiazine or 1,3,2,4-benzodithiadiazine led to Se-(2-aminophenyl)selenosulfate (Se-Bunte salt) or S-(2-aminophenyl)thiosulfate (Bunte salt), respectively. This journal is

A simple and efficient method for synthesis of benzothiazepine derivatives

A series of 1, 5-benzothiazepines were synthesized using disulfides and α, β-unsaturated carbonyl or nitrile compounds as reaction substrates. After reductive cleavage of the S-S bond of disulfides, the resulting thiols were reacted with α,β-unsaturated carbonyl or nitrile compounds to generated seven-membered heterocyclic compounds. In the presence of ammonium thioglycolate, the Michael reaction occurred between disulfides (1) and 4-methyl-3-penten-2-one to give 2, 2, 4-trymethyl-3H-1, 5-benzothiazepine derivatives in good yields. When ethyl acrylate or acrylonitrile was used as the Michael acceptor, 90-99% of (2-amino- phenylsulfanyl)propionitriles (3) and/or 92-99% of (2-amino-phenylsulfanyl) propionic acid ethyl esters (4) were produced. Subsequently, the 1, 5-benzothiazepine compounds 5 and 6 were obtained due to the cyclization reaction. The Japan Institute of Heterocyclic Chemistry.

Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17β-hydroxysteroid dehydrogenase type 3

A novel series of 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitors has been identified. These inhibitors, based on a dibenzazocine core, exhibited picomolar to low nanomolar inhibition of 17β-HSD3 in cell-free enzymatic as well as in cell-based transcriptional reporter assays.

Syntheses of 2,4-diaryl-2,3-dihydro-1,5-benzothiazepines

The condensation of α,β-unsaturated ketones with substituted o-aminothiophenols, obtained by reductive cleavage of the corresponding disulfides in the presence of triphenylphosphine, is an effective method for the synthesis of 2,4-diaryl-2,3-dihydro-1,5-b

New pyrrolobenzothiazepine derivatives as molecular probes of the 'peripheral-type' benzodiazepine receptor (PBR) binding site

A number of new pyrrolobenzothiazepine derivatives and a pyrrolobenzothiazocine derivative have been synthesized and evaluated for their affinity towards the 'peripheral-type' benzodiazepine receptor (PBR). The new compounds were tested in rat cortex, a tissue expressing a high density of mitochondrial PBR. Some of the pyrrolobenzothiazepines exhibited IC50 values in the low nanomolar range as measured by the displacement of [3H]PK 11195 binding. Compound 4i was found to be the most potent ligand for this receptor in the pyrrolobenzothiazepine subgroup with an IC50 practically identical to that determined for PK 11195. Structure-affinity relationships (SARs) have been developed to elucidate the topology of the PBR binding site.

1,4-Benzothiazines

A process for producing novel 1,4-benzothiazine derivatives (I), STR1 (in which X is a halogen atom) and their derivatives, STR2 wherein R is a (C1 -C5) alkyl, (C3 -C6) cycloalkyl, phenyl, substituted phenyl, ph