40925-72-2

Usage

Uses

2-Amino-3-chlorothiophenol can be used as P2Y1 receptor antagonists.

InChI:InChI=1/C6H6ClNS/c7-4-2-1-3-5(9)6(4)8/h1-3,9H,8H2

Upstream product

• 63755-08-8 2-[(2-amino-3-chlorophenyl)dithio]-6-chlorophenylamine 
• 95-51-2 o-chloroaniline 
• 5344-82-1 o-chlorophenylthiourea 
• 137-04-2 2-chloroaniline hydrochloride 
• 351216-87-0 3-Chloro-2-nitro-benzenethiol 
• 27058-83-9 BrH*C₇H₅ClN₂S 

Downstream Products

• 110704-20-6 4-chloro-2-(chloromethyl)benzo[d]thiazole 
• 111281-04-0 2-amino-3-chloro-2'-nitro-3',5'-dibromo diphenylsulphide 
• 137482-47-4 (2-Bromo-phenyl)-(5-chloro-3-methyl-4H-benzo[1,4]thiazin-2-yl)-methanone 
• 121364-12-3 Biphenyl-4-yl-(5-chloro-3-methyl-4H-benzo[1,4]thiazin-2-yl)-methanone 
• 93075-13-9 2-Chloro-6-(2-nitro-phenylsulfanyl)-phenylamine 
• 79838-67-8 2-amino-3-chloro-2'-(3'-nitro-5'-trifluoromethyl)diphenylsulfide 
• 93075-15-1 2-Chloro-6-(2,4-dinitro-phenylsulfanyl)-phenylamine 
• 93075-14-0 4-(2-Amino-3-chloro-phenylsulfanyl)-3-nitro-benzoic acid 
• 526211-18-7 2-chloro-6-(4-chloro-2-nitro-phenylsulfanyl)-phenylamine 
• 875895-77-5 2-(2-amino-3-chloro-phenylsulfanylmethyl)-benzoic acid methyl ester 
• 526211-21-2 N-[2-chloro-6-(4-chloro-2-nitro-phenylsulfanyl)-phenyl]-formamide 
• 143161-11-9 [4-(4-Bromo-2-fluoro-benzyl)-5-chloro-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-2-yl]-acetic acid ethyl ester 
• 111281-07-3 N-[2-Chloro-6-(3,5-dibromo-2-nitro-phenylsulfanyl)-phenyl]-formamide 
• 1910-85-6 1-chlorophenothiazine 

Relevant academic research and scientific papers

Antiviral Compounds

Novel compounds, methods, and compositions for treating various viral infections are described. In some embodiments the novel compounds of the invention are 3-oxo-phenothiazine derivatives; more specific embodiments include 3-oxo-phenothiazine derivatives having substituents at the 1-, 7-, and 9-positions of the phenothiazine parent ring. In other embodiments, the invention provides compositions and methods for treating viral infections, especially HIV.

Synthesis and antimicrobial activity of structurally flexible heterocycles with the 1,4-thiazine heterosystem

In this work, 4H-1,4-benzothiazines were synthesized by an efficient synthetic method in a single step involving heterocyclization of substituted 2-aminobenzenethiols with β-ketoester. The structures of the synthesized compounds were confirmed by their analytical and spectral data. The synthesized compounds were evaluated for their antimicrobial activity against bacterial species; E. coli and Bacillus cereus. The synthesized compounds showed significant activity against microorganisms, which can be correlated with the privileged heterocyclic structural scaffolds.

Novel compounds useful for bradykinin B1 receptor antagonism

Disclosed are compounds that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor.

Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17β-hydroxysteroid dehydrogenase type 3

A novel series of 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitors has been identified. These inhibitors, based on a dibenzazocine core, exhibited picomolar to low nanomolar inhibition of 17β-HSD3 in cell-free enzymatic as well as in cell-based transcriptional reporter assays.

PYRIMIDO-BENZOTHIAZINES

This invention relates to novel pyrimido-benzothiazine derivative compounds. The compounds of the present invention inhibit the action of the lipoxygenase enzyme and are useful in the treatment or alleviation of inflammatory diseases, allergy and cardiovascular diseases in mammals. this invention also relates to pharmaceutical compositions comprising such compounds.

A CONVENIENT AND SINGLE STEP SYNTHESIS OF SUBSTITUTED 4H-BENZOTHIAZINES.

A simple one step synthesis is reported for substituted 4H-benzothiazines involving the condensation of 5-(chloro, bromo, methyl, methoxy, ethoxy)-, 4-methyl- and 3-(chloro and methoxy)-2-aminobenzenethiols with acetylacetone/ethyl acetoacetate/dibenzoylmethane in DMSO.