63759-84-2

Usage

Structure

Benzimidazole derivative with an acetyl group at the 1 position and a phenyl group at the 2 position

Pharmacological properties

Antiviral, antitumor, and anti-inflammatory activities

Potential uses

Treatment of cancer, viral infections, and other medical conditions

Applications

Building block in the synthesis of other pharmaceutical compounds

Versatility

Potential applications in medicine and drug development.

Upstream product

• 75-36-5 acetyl chloride 
• 716-79-0 2-phenyl-1H-benzoimidazole 
• 108-24-7 acetic anhydride 

Relevant academic research and scientific papers

Palladium-catalyzed synthesis of aromatic ketones and isoindolobenzimidazoles via selective aromatic C-H bond acylation

A convenient and efficient palladium-catalyzed synthesis of aromatic ketones and isoindolobenzimidazoles has been developed via selective aromatic C-H bond acylation. The protocol uses palladium acetate as the catalyst, readily available carboxylic acids as the acylating reagents, trifluoroacetic anhydride as the activated agent of the acids, and the corresponding aromatic ketones and isoindolobenzimidazoles were obtained in good to excellent yields. This finding should provide a new and useful strategy for synthesis of aromatic ketones and isoindolobenzimidazoles.

A way to obtain cyclopalladation of unsubstituted 2-phenylimidazole derivatives

This work shows the difficulties of obtaining cyclopalladated complexes with 2-phenylimidazole and 2-phenylbenzimidazole as ligands. The protection of the NH group in the heterocycle with an acetyl group allows the formation of several cyclopalladated com