637739-99-2

Usage

Uses

Used in Pharmaceutical Industry:
(2-azabicyclo[2.1.1]hex-1-yl)-methanol is used as an intermediate in the synthesis of various pharmaceuticals due to its unique bicyclic structure and functional groups. This allows for the development of new drugs with specific therapeutic properties.
Used in Organic Synthesis:
In the field of organic synthesis, (2-azabicyclo[2.1.1]hex-1-yl)-methanol can be utilized as a building block for the creation of more complex organic molecules. Its versatility in forming different chemical bonds makes it a valuable component in the synthesis of specialty chemicals.
Used in Chemical Research:
(2-azabicyclo[2.1.1]hex-1-yl)-methanol may also serve as a subject of interest in chemical research. Its unique structure and properties can be investigated to understand its reactivity, stability, and potential interactions with other molecules, which can lead to new insights and applications in chemistry.

Upstream product

• 637739-94-7 (2-benzyl-2-azabicyclo[2.1.1]hex-1-yl)methanol 
• 637739-93-6 2-benzoyl-2-azabicyclo[2.1.1]hexane-1-carboxylic acid ethyl ester 
• 637739-92-5 2-(allyl-benzoyl-amino)-acrylic acid ethyl ester 

Downstream Products

• 637740-10-4 1-imidazol-1-ylmethyl-2-aza-bicyclo[2.1.1]hexane-2-carboxylic acid benzyl ester 
• 637740-06-8 1-methanesulfonyloxymethyl-2-azabicyclo[2.1.1]hexane-2-carboxylic acid benzyl ester 
• 637740-08-0 1-cyanomethyl-2-azabicyclo[2.1.1]hexane-2-carboxylic acid benzyl ester 
• 637740-15-9 1-formyl-2-azabicyclo[2.1.1]hexane-2-carboxylic acid benzyl ester 
• 637740-11-5 1-imidazol-1-ylmethyl-2-azabicyclo[2.1.1]hexane 
• 637739-98-1 1-hydroxymethyl-2-azabicyclo[2.1.1]hexane-2-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Escaping from Flatland: Substituted Bridged Pyrrolidine Fragments with Inherent Three-Dimensional Character

The pressure to deliver new medicines to the patient continues to grow along with increases in compound failure rate, thus putting the current R&D model at risk. Analysis has shown that increasing the three-dimensionality of potential drug candidates decreases the risk of failure and improves binding selectivity and frequency. For this reason many workers have taken a new look at the power of photochemistry as a means to generate novel sp3 rich scaffolds for use in drug discovery programs. Here we report the design, synthesis, and computational structural analysis of a series of 2,4-methanoprolines having inherent 3D character (PMI and PBF scores) significantly higher than that of the broader AbbVie Rule of 3 (Ro3) collection.

Modification of 1-Substituents in the 2-Azabicyclo[2.1.1]hexane Ring System; Approaches to Potential Nicotinic Acetylcholine Receptor Ligands from 2,4-Methanoproline Derivatives

Successful nucleophilic substitution at a methylene attached to the bridgehead (1-) position of the 2-azabicyclo[2.1.1]hexane ring system opens the way to construction of novel derivatives having a wider range of functional groups attached to the 1-positi