637762-35-7Relevant academic research and scientific papers
Pd-catalyzed enantioselective allyl-allyl cross-coupling
Zhang, Ping,Brozek, Laura A.,Morken, James P.
supporting information; scheme or table, p. 10686 - 10688 (2010/11/04)
The Pd-catalyzed cross-coupling of allylic carbonates and allylB(pin) is described. The regioselectivity of this reaction is sensitive to the bite angle of the ligand, with small-bite-angle ligands favoring the branched substitution product. This mode of
The enantioselective organocatalytic 1,4-addition of electron-rich benzenes to α,β-unsaturated aldehydes
Paras, Nick A.,MacMillan, David W. C.
, p. 7894 - 7895 (2007/10/03)
The first enantioselective organocatalytic alkylation of electron-rich benzene rings with α,β-unsaturated aldehydes has been accomplished. The use of iminium catalysis has provided a new strategy for the enantioselective construction of benzylic stereogenicity, an important chiral synthon for natural product and medicinal agent synthesis. The (2S,5S)-5-benzyl-2-tert-butylimidazolidinone amine catalyst has been found to mediate the conjugate addition of a wide variety of substituted and unsubstituted anilines to unsaturated aldehydes. A diverse spectrum of aldehyde substrates can also be accommodated in this new organocatalytic transformation. While catalyst quantities of 10 mol % were generally employed in this study, successful alkylations conducted with catalyst loadings as low as 1 mol % are described. Copyright
