63777-58-2Relevant academic research and scientific papers
N-(3,4-dichlorobenzyl)azoles - Investigations regarding synthesis, NMR-spectroscopy and affinity towards sigma-1 and sigma-2 receptors
Holzer, Wolfgang,Brandst?tter, Bettina,J?ger, Christine,Kaun, Michael,Langer, Thierry,Bowen, Wayne D.
, p. 197 - 211 (2004)
A series of azoles and aminoazoles with a 3,4-dichlorobenzyl moiety attached to a ring nitrogen atom was synthesized via reaction of the parent systems with 3,4-dichlorobenzyl chloride. Regioisomeric products were discriminated on the basis of 13C-NMR data or by NOE-difference spectroscopy. The affinities of some representatives towards sigma-1 and sigma-2 receptors were determined by receptor binding assays.
