Scientia Pharmaceutica p. 197 - 211 (2004)
Update date:2022-08-04
Topics:
Holzer, Wolfgang
Brandst?tter, Bettina
J?ger, Christine
Kaun, Michael
Langer, Thierry
Bowen, Wayne D.
A series of azoles and aminoazoles with a 3,4-dichlorobenzyl moiety attached to a ring nitrogen atom was synthesized via reaction of the parent systems with 3,4-dichlorobenzyl chloride. Regioisomeric products were discriminated on the basis of 13C-NMR data or by NOE-difference spectroscopy. The affinities of some representatives towards sigma-1 and sigma-2 receptors were determined by receptor binding assays.
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