N-(3,4-dichlorobenzyl)azoles - Investigations regarding synthesis, NMR-spectroscopy and affinity towards sigma-1 and sigma-2 receptors

Article abstract of DOI:10.3797/scipharm.aut-04-16

A series of azoles and aminoazoles with a 3,4-dichlorobenzyl moiety attached to a ring nitrogen atom was synthesized via reaction of the parent systems with 3,4-dichlorobenzyl chloride. Regioisomeric products were discriminated on the basis of ¹³C-NMR data or by NOE-difference spectroscopy. The affinities of some representatives towards sigma-1 and sigma-2 receptors were determined by receptor binding assays.