63778-18-7

Basic information

• Product Name: Benzene, 1-(1-azidoethyl)-2-chloro-
• CAS NO: 63778-18-7
• Molecular Formula: C8H8ClN3
• Molecular Weight: 181.625
• Mol File: 63778-18-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(1-azidoethyl)-2-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(1-azidoethyl)-2-chloro-(63778-18-7)
• EPA Substance Registry System: Benzene, 1-(1-azidoethyl)-2-chloro-(63778-18-7)

Safety Data

• Hazardous Substances Data: 63778-18-7(Hazardous Substances Data)

Upstream product

• 13524-04-4 2'-chloro-sec-phenethyl alcohol 
• 1796-62-9 (+/-)-1-(2-chlorophenyl)ethyl acetate 

Downstream Products

• 185317-57-1 1-(1-Phenyl-ethyl)-1H-[1,2,3]triazole-4,5-dicarboxylic acid dimethyl ester 
• 185317-59-3 (+/-)-1-(α-Methylbenzyl)-1H-1,2,3-triazole-4,5-dicarboxyhydrazide 
• 185317-62-8 1-(1-Phenyl-ethyl)-1H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-diol 

Relevant articles and documents

One-pot green synthesis of azides from alcohols using bronsted acidic ionic liquid [HMIM][BF4] as solvent and catalyst

Bronsted acidic ionic liquid, [HMIM][BF4], has been used as a non-volatile, eco-friendly solvent, and catalytic medium for the one-pot green synthesis of azides from corresponding alcohols. The [HMIM][BF 4] showed high reactivity than [BMIM][BF4] and [BMIM][PF6], affording azides in up to 97% yield, which could be easily separated from the reaction mixture. The ease of recyclability of [HMIM][BF4] makes the reaction economically and potentially viable for practical applications. Azides are versatile substrates in organic synthesis and serve as convenient intermediate in the synthesis of pharmaceutical heterocycles and natural products. By using dual functional [HMIM][BF 4] as solvent and catalyst, efficient synthesis of azides from their corresponding alcohols have been undertaken under eco-friendly conditions. This study may pave the way for practical application of [HMIM][BF4] in cholesterylamine synthesis.

Copper(II) triflate as a double catalyst for the one-pot click synthesis of 1,4-disubstituted 1,2,3-triazoles from benzylic acetates

Copper(II) triflate doubly catalyzed the substitution of benzylic acetates by TMSN3 and the subsequent 1,3-dipolar addition with an alkyne in one pot. This procedure afforded the preparation of 1,4-disubstituted 1,2,3-triazoles in good yields starting from the easily accessible acetates without isolating an organic azide using a single catalyst. Georg Thieme Verlag Stuttgart.