63810-80-0

Basic information

• Product Name: 2,3-DICHLORO-6,7-DIMETHYLQUINOXALINE
• Synonyms: 2,3-DICHLORO-6,7-DIMETHYLQUINOXALINE;AKOS BBS-00001440;2,3-dichloro-6,7-dimethylquinoxaline(SALTDATA: FREE);2,3-Dichloro-6,7-dimethyl-1,4-benzodiazine
• CAS NO: 63810-80-0
• Molecular Formula: C₁₀H₈Cl₂N₂
• Molecular Weight: 227.09
• Mol File: 63810-80-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 312.4 °C at 760 mmHg
• Flash Point: 171.8 °C
• Appearance: /
• Density: 1.364 g/cm³
• Vapor Pressure: 0.000971mmHg at 25°C
• Refractive Index: 1.636
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,3-DICHLORO-6,7-DIMETHYLQUINOXALINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DICHLORO-6,7-DIMETHYLQUINOXALINE(63810-80-0)
• EPA Substance Registry System: 2,3-DICHLORO-6,7-DIMETHYLQUINOXALINE(63810-80-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 63810-80-0(Hazardous Substances Data)

Usage

General Description

2,3-Dichloro-6,7-dimethylquinoxaline is a chemical compound with the molecular formula C10H8Cl2N2. It is a yellow to brown solid that is insoluble in water and most organic solvents. 2,3-DICHLORO-6,7-DIMETHYLQUINOXALINE has been used in research as a starting material for the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential use as a corrosion inhibitor and in the development of new materials. However, it is important to handle this compound with care as it can be toxic and harmful if ingested or inhaled.

InChI:InChI=1/C10H8Cl2N2/c1-5-3-7-8(4-6(5)2)14-10(12)9(11)13-7/h3-4H,1-2H3

Upstream product

• 2474-50-2 2.3-Dihydroxy-6.7-dimethyl-chinoxalin 
• 3171-45-7 4,5-dimethyl-1,2-phenylenediamine 
• 2474-50-2 6,7-dimethyl-1,4-dihydroquinoxaline-2,3-dione 

Downstream Products

• 31102-93-9 6,7-dimethyl-3-phenyl-3H-thiazolo[4,5-b]quinoxalin-3-ylideneamine 
• 31200-21-2 (6,7-dimethyl-thiazolo[4,5-b]quinoxalin-2-yl)-phenyl-amine 
• 130064-16-3 2,3-dimethoxy-6,7-dimethylquinoxaline 

Relevant articles and documents

Novel molecular targeting anti-tumor aza-steroid derivative based on lipid toxicity and preparation and application thereof

The invention provides a novel molecular targeting anti-tumor aza-steroid derivative based on lipid toxicity and a preparation method and application thereof, and belongs to the field of chemical medicines. The derivative is a compound as shown in a formula I, or a salt thereof, or a stereoisomer thereof. The compound is low in toxicity or basically non-toxic to normal cells, has an obvious inhibition effect to tumor cell lines, particularly has good lipid toxicity selectivity to tumor cells such as liver cancer, lung cancer and the like in vivo, and has an obvious inhibition effect; meanwhile, the compound can effectively activate SREBP1 and PPAR gamma, inhibit lipid transport MTTP, cause lipid aggregation in tumor cells and cause lipid toxicity of the tumor cells. The compound can be used for treating liver cancer, lung cancer and the like in a molecular targeting manner, is low in toxicity or even non-toxic, and has a good application prospect.

Method for preparing 2,3-dichloro-quinoxaline derivative through one-pot procedure

The invention belongs to the field of drug synthesis, and specifically relates to a new method for preparing 2,3-dichloro-quinoxaline derivative through one-pot procedure. According to the method, cheap o-phenylenediamine and oxalic acid are adopted as raw materials, and the cheap and easily available and environmentally friendly silica gel or methanesulfonic acid is adopted as a catalyst while steps of intermediate separation and purification are omitted; the method has the advantages of easiness in operation, low cost, mild reaction conditions and environmental friendliness and promotes industrial mass production.

The syntheses of pyrazino-containing sultines and their application in Diels-Alder reactions with electron-poor olefins and [60]fullerene

The Diels-Alder reactions of heterocyclic o-quinodimethanes, generated in situ from 6,7-disubstituted quinoxalino[2,3-d]-[1,2λ4]oxathiine 2-oxides (6a-c), 2,3-disubstituted-8,9-dihydro-6H-8λ 4-[1,2]oxathiino[4,5-g]quinoxalin-8-one (7a-c) (sultines), and pyrazinosultine (22), with electron-poor olefins and [60]fullerene are described. The heterocyclic-fused sultines 7a-c and 22 are readily prepared from the corresponding dibromides 9a-c and 24 with the commercially available Rongalite (sodium formaldehyde sulfoxylate). When heated in the presence of electron-poor dienophiles and [60]fullerene, all of the sultines underwent extrusion of SO2, and the resulting heterocyclic o-quinodimethanes (3a-d, 4a-c, and 25) were intercepted as the 1:1 adducts in good to excellent yields. The temperature-dependent 1H NMR spectra of fullerene derivatives 31-38 show a dynamic process for the methylene protons. The activation free energies (ΔGc?) determined for the boat-to-boat inversion of these pyrazino-containing C60 compounds (31-34 and 38) are found to be in the range of 14.1-14.8 kcal/mol, but they are in the range of 15.2 to >17.1 kcal/mol for adducts 35-37. The activation free energies (ΔGC?) are significantly affected by (1) the orientations and (2) the substituents of the quinoxaline rings and (3) the extended benzannulation in the arenes of C60 adducts (see Table 2), which implies that both electronic interactions and steric effects between the aromatic addends and C60 are important. Tautomerization of methylquinoxaline to its enamine is invoked as a rationalization for the lowering of ΔGC? in some of the fulleroadducts.