130064-16-3

Usage

Derivative of quinoxaline

Quinoxaline is a heterocyclic organic compound with a ring structure containing two nitrogen atoms. 2,3-Dimethoxy-6,7-dimethylquinoxaline is a modified version of 2,3-Dimethoxy-6,7-dimethylquinoxaline.

Methoxy and methyl groups

The compound has two methoxy (CH3O) groups and two methyl (CH3) groups attached to the quinoxaline ring, which influence its chemical properties and reactivity.

Organic synthesis building block

2,3-Dimethoxy-6,7-dimethylquinoxaline is used in organic synthesis as a starting material for constructing more complex compounds.

Potential applications

The compound may have potential uses in the pharmaceutical and agricultural industries, depending on the context of its application. Its specific uses and properties may vary in different settings.

Upstream product

• 124-41-4 sodium methylate 
• 63810-80-0 2,3-dichloro-6,7-dimethylquinoxaline 
• 3171-45-7 4,5-dimethyl-1,2-phenylenediamine 
• 2474-50-2 6,7-dimethyl-1,4-dihydroquinoxaline-2,3-dione 

Relevant academic research and scientific papers

1,4-Dihydro-2,3-quinoxalinediones as potential flavin metabolites and excitatory amino acid receptor ligands. Part 1: Synthesis and pharmacological evaluation of the benzylic oxidation series of 1,4-dihydro-6,7-dimethyl-2,3- quinoxalinedione

A series of five 6,7-disubstituted 1,4-dihydro-2,3-quinoxalinediones was prepared, two of which are known microbial flavin metabolites and three of which are potential flavin metabolites. Four of the five compounds inhibited specific binding of [3H]-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid ([3H]AMPA), [3H]kainic acid, and [3H]6-cyano-1,4-dihydro-7-nitro-2,3- quinoxalinedione ([3H]CNQX) in rat brain homogenate fractions, with IC50 values in the low micromolar range (the fifth compound competed only with [3H]CNQX). Two of the compounds were moderately potent AMPA antagonists in an in vitro functional test.

Kynurenic Acid Derivatives. Structure-Activity Relationships for Excitatory Amino Acid Antagonism and Identification of Potent and Selective Antagonists at the Glycine Site of the N-Methyl-D-aspartate Receptor

Derivatives of the nonselective excitatory amino acid antagonist kynurenic acid (4-oxo-1,4-dihydroquinoline-2-carboxylic acid, 1) have been synthesized and evaluated for in vitro antagonist activity at the excitatory amino acid receptors sensitive to N-me