638136-51-3

Usage

Uses

Used in Pharmaceutical Industry:
2,4(1H,3H)-Pyrimidinedione, 6-amino-1-[(2-chlorophenyl)methyl]is used as a building block for the synthesis of diverse bioactive compounds. Its unique structural features, including the 6-amino group and the 2-chlorophenylmethyl moiety, make it a valuable intermediate in the development of new pharmaceuticals with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical field, 2,4(1H,3H)-Pyrimidinedione, 6-amino-1-[(2-chlorophenyl)methyl]serves as a key intermediate in the production of various agrochemicals. Its chemical properties allow for the creation of compounds with pesticidal, herbicidal, or other agricultural applications, contributing to the development of more effective and targeted agrochemical products.

Upstream product

• 4654-63-1 1-(2-chlorophenyl)methylurea 
• 105-56-6 ethyl 2-cyanoacetate 

Relevant academic research and scientific papers

Synthesis and evaluation of antitumour activities of novel fused tri-And tetracyclic uracil derivatives

Simple one-pot syntheses of indenopyrrolopyrimidines and indolopyrrolopyrimidines were achieved via the cyclocondensation of 6-Aminouracils and, respectively, ninhydrin and isatin in the presence of catalytic amounts of glacial acetic acid. Similarly, 5,6-diaminouracil derivatives were used as starting materials for the synthesis of indenopteridines and indolopteridines via their reaction with ninhydrin and isatin, respectively. The synthesised compounds were evaluated for antitumour activity against a human hepatocellular carcinoma cell line (HepG2), some showing antitumour activity comparable with 5-fluorouracil and imatinib.

6-Aminouracils as precursors for the syntheses of fused di- and tricyclic

The treatment of 1-benzyl-, or 1-methyl-6-chlorouracil (1a,b) with nucleophilic primary amines followed by nitrosation, reduction, formylation and dehydro-cyclisation lead to xanthines 5 and 7. While, the treatment of uracil 8 with aromatic aldehydes 9a-f leads to the formation of dipyrimidinopyridines 10a-f, reaction with formalin and primary amines gives pyrimidopyrimidines 11a-d via double Michael reactions.