638141-30-7

Usage

Molecular Weight

334.24 g/mol The molecular weight of 2-(4-bromophenyl)-1-ethyl-1H-benzimidazole is 334.24 g/mol, which is the sum of the atomic weights of all the atoms in the molecule.

Structure

2-(4-bromophenyl)-1-ethyl-1H-benzimidazole has a benzimidazole core, with a bromophenyl group at the 4-position and an ethyl group at the 1-position.

Biological Activity

2-(4-bromophenyl)-1-ethyl-1H-benzimidazole has been studied for its potential antifungal, antibacterial, and anticancer properties, indicating that it may have therapeutic potential in the treatment of these diseases.

Medicinal Chemistry Research

The chemical structure and functional groups of 2-(4-bromophenyl)-1-ethyl-1H-benzimidazole make it a valuable tool for medicinal chemistry research, as it can be used as a starting point for the development of new drugs with improved properties.

Organic Synthesis

2-(4-bromophenyl)-1-ethyl-1H-benzimidazole is used in organic synthesis, as it can be used as a building block for the synthesis of more complex molecules.

Drug Discovery

2-(4-bromophenyl)-1-ethyl-1H-benzimidazole is being investigated as a potential therapeutic agent for various diseases, indicating its potential for use in drug discovery and development.

Upstream product

• 2622-74-4 2-(4-bromophenyl)-1H-benzimidazole 
• 586-76-5 4-Bromobenzoic acid 
• 623-00-7 4-bromobenzenecarbonitrile 
• 74-96-4 ethyl bromide 

Downstream Products

• 1352574-74-3 methyl (2E)-3-[4-(1-ethyl-1H-benzimidazol-2-yl)phenyl]acrylate 
• 1352574-77-6 ethyl (2E)-3-[4-(1-ethyl-1H-benzimidazol-2-yl)phenyl]acrylate 
• 1142382-38-4 C₂₂H₂₄N₂O₂ 

Relevant academic research and scientific papers

Neutral heteroleptic cyclometallated Platinum(II) complexes featuring 2-phenylbenzimidazole ligand as bright emitters in solid state and in solution

A series of 8 neutral cyclometallated platinum(II) complexes featuring 2-phenylbenzimidazole chromophoric ligand and acetylacetonate as ancillary ligand has been synthesized and characterized. The introduction of a variety of substituent on the phenyl ring allows to finely tune the emission wavelength. The emission data reveal high quantum yield in deaerated solution and in bulk solid state (micro-crystalline powder), with values up to an impressive 51%. The emission for all of the complexes is attributed to a mixed 3LC-MLCT state. Both absorption and emission data have been correlated successfully with the redox potentials and the Hammett parameters.

Intramolecular C(sp3)–H Imination towards Benzimidazoles Using Tetrabutylammonium Iodide and tBuOOH

Development of sustainable and economically viable methods is challenging but desired in organic synthesis. Herein, intramolecular C(sp3)–H imination between a free amine group and N-methylene group is established using TBAI (20 mol %)-TBHP (3.0 equiv.) in DMSO which is found to be an inexpensive replacement of PhI-mCPBA in HFIP.

Synthesis and optical properties of novel fluorescence-traced benzimidazolium bromides

Seven novel fluorescence-traced 1-aryl-2-substituted-3-allyl-1H- benzimidazolium bromides (5a, 5b, 5c, 5d, 5e, 5f, 5g) were synthesized by alkylation and quaternization of compounds 1-aryl-2-substituted-1H- benzimidazoles (4a, 4b, 4c, 4d, 4e, 4f, 4g) with excess allyl bromide in acetonitrile at refluxing temperature. Their structures were characterized by 1H-NMR, MS, and elemental analysis. They emit violet-blue light (λEmmax = 386-438 nm) with fluorescence quantum yields of 0.54 to 0.75 in aqueous solution.

Synthesis, characterization, optical properties and theoretical calculations of blue light-emitting 1-alkyl-2-substituted benzimidazoles

A series of novel blue light-emitting 1-alkyl-2-substituted benzimidazoles (4a-4g) were synthesized by reactions of the 2-substituted benzimidazoles (3a-3e) with ethyl bromide or n-butyl bromide as electrophilic reagent. Compounds 3a, 3c, 3e were synthesized by the condensation of 1a-1c with 1,2-diamino benzene o-phenylene diamine using air as oxidizing agent and compounds 3b, 3d were synthesized by the condensation of 2d-2e with 1,2-diamino benzene o-phenylene diamine using phosphoric acid and polyphosphoric acid as catalyst. Their optical properties were investigated by UV-visible spectroscopy and photoluminescence techniques in solution. They emit violetblue light (lEm max = 380-440 nm) with fluorescence quantum yields of 0.43 to 0.92 while diluted in acetonitrile solution. In order to find the relationship between the structures and properties of compounds 4a-4g, theoretical calculations using density functional theory at the B3LYP/6-31g*level were also studied.

Synthesis and antibacterial activity of some novel N-substituted 3-[4-(1-alkyl/acyl/aroyl-1H-benzimidazol-2-yl)phenyl]acrylate derivatives

Synthesis of a series of novel 3-[4-(1-alkyl/acyl/aroyl-1H-benzimidazol-2- yl)phenyl]acrylate derivatives has been reported. These derivatives are prepared by condensation of o-phenyle-nediamine with 4-bromobenzoic acid to give 2-(4-bromophenyl)-1H-benzimidazole which undergoes Heck reaction with alkyl acrylates to give the above benzimidazole derivatives. Subsequent reactions of these compounds with different types of electrophiles afford a series of the corresponding 1N-substituted alkyl/acyl/-aroyl/sulfonyl derivatives. Furthermore, the antibacterial activities of these compounds have been checked against Staphylococcus aureus and Salmonella typhimurium bacterial strains but the results are found to be disappointing.