63816-09-1

Basic information

• Product Name: 1-benzyl-6-methoxyquinolin-2(1H)-one
• Synonyms: 1-Benzyl-6-methoxyquinolin-2(1H)-one; 2(1H)-quinolinone, 6-methoxy-1-(phenylmethyl)-
• CAS NO: 63816-09-1
• Molecular Formula: C₁₇H₁₅NO₂
• Molecular Weight: 265.3065
• Mol File: 63816-09-1.mol

Chemical Properties

• Boiling Point: 435.6°C at 760 mmHg
• Flash Point: 217.3°C
• Density: 1.209g/cm³
• Vapor Pressure: 8.64E-08mmHg at 25°C
• Refractive Index: 1.625
• CAS DataBase Reference: 1-benzyl-6-methoxyquinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-6-methoxyquinolin-2(1H)-one(63816-09-1)
• EPA Substance Registry System: 1-benzyl-6-methoxyquinolin-2(1H)-one(63816-09-1)

Safety Data

• Hazardous Substances Data: 63816-09-1(Hazardous Substances Data)

Usage

Chemical class

Quinoline

Molecular structure

Heterocyclic with a quinoline core

Substitution

Benzyl group at position 1, methoxy group at position 6

Biological activities

Anti-inflammatory, antioxidant, and anti-cancer

Potential applications

Medicinal chemistry, drug discovery

New drug development

Treatment of various diseases and disorders

Upstream product

• 5263-87-6 6-methoxy quinoline 
• 100-39-0 benzyl bromide 

Relevant articles and documents

Base-promoted aerobic oxidation of: N -alkyl iminium salts derived from isoquinolines and related heterocycles

Potassium tert-butoxide-promoted aerobic oxidation of N-alkyl iminium salts is reported. The reaction is atom-economical and environmentally friendly. Iminium salts derived from isoquinoline, quinoline, phenanthridine, phenanthroline, and phthalazine were successfully transformed into their corresponding unsaturated lactams with up to 95% yield under mild conditions in the absence of photocatalysts and metallic or organic catalysts. Owing to the general substrate scope, low cost, feasibility of scale up, wide availability of reagents, and green reaction conditions, this method shows great potential for preparing isoquinolones and related compounds. The method was applied for atom- and step-economical total synthesis of natural products such as norketoyobyrine.