638192-11-7Relevant articles and documents
Identification and characterization of amino-piperidinequinolones and quinazolinones as MCHr1 antagonists
Blackburn, Christopher,LaMarche, Matthew J.,Brown, James,Che, Jennifer Lee,Cullis, Courtney A.,Lai, Sujen,Maguire, Martin,Marsilje, Thomas,Geddes, Bradley,Govek, Elizabeth,Kadambi, Vivek,Doherty, Colleen,Dayton, Brian,Brodjian, Sevan,Marsh, Kennan C.,Collins, Christine A.,Kym, Philip R.
, p. 2621 - 2627 (2007/10/03)
Several potent, functionally active MCHr1 antagonists derived from quinolin-2(1H)-ones and quinazoline-2(1H)-ones have been synthesized and evaluated. Pyridylmethyl substitution at the quinolone 1-position results in derivatives with low-nM binding potency and good selectivity with respect to hERG binding.