6384-10-7Relevant academic research and scientific papers
Lipodiscamides A-C, new cytotoxic lipopeptides from discodermia kiiensis
Tan, Karen Co,Wakimoto, Toshiyuki,Abe, Ikuro
supporting information, p. 3256 - 3259 (2014/07/08)
Lipodiscamides A-C, three new lipodepsipeptides, were characterized from the marine sponge Discodermia kiiensis. These structurally rare cyclic lipodepsipeptides were found to possess an unprecedented dilactone macrocycle and, thus, represent a new family of lipopeptides. They are the only lipopeptides bearing 4S-hydroxy-trans-2-enoate, and noncanonical amino acids, l-3-ureidoalanine (Uda), E-dehydronorvaline (Denor), and d-citrulline (Cit). MTT assays against P388 and HeLa cells revealed the moderate cytotoxicity of all three compounds.
Ceric ammonium nitrate (CAN) mediated esterification of N-Boc amino acids allows either retention or removal of the N-Boc group
Kuttan, Ashani,Nowshudin, Shiek,Rao
, p. 2663 - 2665 (2007/10/03)
Reaction of N-Boc amino acids with ceric ammonium nitrate in an alcohol as the solvent at room temperature resulted in the esterification of N-Boc amino acids with Boc group retention. When the reaction was conducted at reflux temperature, esterification was accompanied with simultaneous removal of the Boc group. Both reactions gave the desired products in good yields.
Synthesis and Evaluation of Novel Spermidine Derivatives as Targeted Cancer Chemotherapeutic Agents
Stark, Peter A.,Thrall, Brian D.,Meadows, Gary G.,Abdel-Monem, Mahmoud M.
, p. 4264 - 4269 (2007/10/02)
The utility of the spermidine moiety as the homing device for the selective delivery of chemotherapeutic and diagnostic agents into cancer cells was explored.Two spermidine analogs containing a cytotoxic agent were synthesized, N-3,4-bis(benzyloxy)phenet
